FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983016906> ?p ?o ?g. }

• W1983016906 endingPage "125" @default.
• W1983016906 startingPage "120" @default.
• W1983016906 abstract "Adminstration of 1-methyl-4-phenyl-pyridinium ion (MPP+) into the lateral ventricle of mice induced clonic convulsions and lethality in a dose- and age-dependent manner. MPP+ failed to induce seizures in 4-day-old mice, and the convulsant response to MPP+ was enhanced in aged mice. The seizures triggered by MPP+ in adult mice were blocked by coadministration of L-glutamate antagonists active at kainate/AMPA receptors such as α-D-glutamylaminomethylsulphonate and 2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo[f]quinoxaline. The N-methyl-D-asparate (NMDA) antagonist 2-amino-7-phosphonoheptanoate, but not kynurenate, also protected mice against MPP+ convulsions. Similarly, the benzodiazepine midazolam and the adenosine A1 agonist 2-chloroadenosine, but not antiepileptic drugs such as phenobarbital, trimethadione, ethosuximide, or acetazolamide, showed a protective efficacy against seizures. Additionally, the excitatory amino acid antagonists as well as phenobarbital, midazolam and 2-chloradenosine protected mice against MPP+ lethality. These data suggest that convulsant action of MPP+ and its lethality in rodents may be mediated by excitatory amino acids." @default.
• W1983016906 created "2016-06-24" @default.
• W1983016906 creator A5012217259 @default.
• W1983016906 creator A5034090984 @default.
• W1983016906 date "1992-02-01" @default.
• W1983016906 modified "2023-10-16" @default.
• W1983016906 title "Excitatory amino acid antagonists protect mice against MPP+ seizures" @default.
• W1983016906 cites W1534709134 @default.
• W1983016906 cites W1607076327 @default.
• W1983016906 cites W1969800514 @default.
• W1983016906 cites W1972028705 @default.
• W1983016906 cites W1989645955 @default.
• W1983016906 cites W1990015622 @default.
• W1983016906 cites W1990296246 @default.
• W1983016906 cites W1991511436 @default.
• W1983016906 cites W1997243628 @default.
• W1983016906 cites W2001664062 @default.
• W1983016906 cites W2003189253 @default.
• W1983016906 cites W2026606626 @default.
• W1983016906 cites W2035667968 @default.
• W1983016906 cites W2041734419 @default.
• W1983016906 cites W2044779910 @default.
• W1983016906 cites W2052499518 @default.
• W1983016906 cites W2054007800 @default.
• W1983016906 cites W2057643090 @default.
• W1983016906 cites W2075056521 @default.
• W1983016906 cites W2077210543 @default.
• W1983016906 cites W2078062505 @default.
• W1983016906 cites W2089775599 @default.
• W1983016906 cites W2095358033 @default.
• W1983016906 cites W2136602798 @default.
• W1983016906 cites W2178105210 @default.
• W1983016906 cites W2444475331 @default.
• W1983016906 doi "https://doi.org/10.1002/syn.890100206" @default.
• W1983016906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1585255" @default.
• W1983016906 hasPublicationYear "1992" @default.
• W1983016906 type Work @default.
• W1983016906 sameAs 1983016906 @default.
• W1983016906 citedByCount "8" @default.
• W1983016906 countsByYear W19830169062017 @default.
• W1983016906 crossrefType "journal-article" @default.
• W1983016906 hasAuthorship W1983016906A5012217259 @default.
• W1983016906 hasAuthorship W1983016906A5034090984 @default.
• W1983016906 hasConcept C112592302 @default.
• W1983016906 hasConcept C115955781 @default.
• W1983016906 hasConcept C160268369 @default.
• W1983016906 hasConcept C169760540 @default.
• W1983016906 hasConcept C170493617 @default.
• W1983016906 hasConcept C185592680 @default.
• W1983016906 hasConcept C189184402 @default.
• W1983016906 hasConcept C2775858608 @default.
• W1983016906 hasConcept C2778186239 @default.
• W1983016906 hasConcept C2778793413 @default.
• W1983016906 hasConcept C2778900099 @default.
• W1983016906 hasConcept C2779619453 @default.
• W1983016906 hasConcept C2911067986 @default.
• W1983016906 hasConcept C55493867 @default.
• W1983016906 hasConcept C61174792 @default.
• W1983016906 hasConcept C67018056 @default.
• W1983016906 hasConcept C71924100 @default.
• W1983016906 hasConcept C86803240 @default.
• W1983016906 hasConcept C98274493 @default.
• W1983016906 hasConceptScore W1983016906C112592302 @default.
• W1983016906 hasConceptScore W1983016906C115955781 @default.
• W1983016906 hasConceptScore W1983016906C160268369 @default.
• W1983016906 hasConceptScore W1983016906C169760540 @default.
• W1983016906 hasConceptScore W1983016906C170493617 @default.
• W1983016906 hasConceptScore W1983016906C185592680 @default.
• W1983016906 hasConceptScore W1983016906C189184402 @default.
• W1983016906 hasConceptScore W1983016906C2775858608 @default.
• W1983016906 hasConceptScore W1983016906C2778186239 @default.
• W1983016906 hasConceptScore W1983016906C2778793413 @default.
• W1983016906 hasConceptScore W1983016906C2778900099 @default.
• W1983016906 hasConceptScore W1983016906C2779619453 @default.
• W1983016906 hasConceptScore W1983016906C2911067986 @default.
• W1983016906 hasConceptScore W1983016906C55493867 @default.
• W1983016906 hasConceptScore W1983016906C61174792 @default.
• W1983016906 hasConceptScore W1983016906C67018056 @default.
• W1983016906 hasConceptScore W1983016906C71924100 @default.
• W1983016906 hasConceptScore W1983016906C86803240 @default.
• W1983016906 hasConceptScore W1983016906C98274493 @default.
• W1983016906 hasIssue "2" @default.
• W1983016906 hasLocation W19830169061 @default.
• W1983016906 hasLocation W19830169062 @default.
• W1983016906 hasOpenAccess W1983016906 @default.
• W1983016906 hasPrimaryLocation W19830169061 @default.
• W1983016906 hasRelatedWork W1519801794 @default.
• W1983016906 hasRelatedWork W1752827062 @default.
• W1983016906 hasRelatedWork W1776849394 @default.
• W1983016906 hasRelatedWork W1978030967 @default.
• W1983016906 hasRelatedWork W1980062692 @default.
• W1983016906 hasRelatedWork W1983016906 @default.
• W1983016906 hasRelatedWork W2075068097 @default.
• W1983016906 hasRelatedWork W2093895176 @default.
• W1983016906 hasRelatedWork W2129383232 @default.
• W1983016906 hasRelatedWork W2432488247 @default.
• W1983016906 hasVolume "10" @default.
• W1983016906 isParatext "false" @default.

• next