Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983036150> ?p ?o ?g. }
- W1983036150 endingPage "1154" @default.
- W1983036150 startingPage "1144" @default.
- W1983036150 abstract "Barbel (Barbus graellsii) is a freshwater fish used as a sentinel species in environmental monitoring programmes and ecotoxicological studies in northern Spain, particularly in the Ebro River basin, the largest freshwater resource in Spain. We developed specific primers for the quantification of CYP1A and metallothionein (MT)-1 and -2 gene expression by QRT-PCR in barbel in order to assess their suitability in biological effect monitoring of dioxin-like compounds and metals. All three genes responded as expected in laboratory tests, using model inducers. Hepatic CYP1A mRNA levels showed a twofold induction in fish injected intraperitoneally with beta-naphthoflavone, whereas MT-1 and MT-2 gene expression was strongly induced by cadmium (15- and 13-fold, respectively) and mercury (five- and eightfold). Barbel populations from different sites on the Ebro River basin showed a good correlation between the historical records of organochlorine pollution, CYP1A expression levels and EROD activity. Nevertheless, although metallothionein protein levels in the liver of wild fish correlated with hepatic levels of mercury, MT-1 and MT-2 gene expression did not correlate with the mercury content or with the concentration of metals in sediments from the sites inhabited by the fish. These results demonstrate the utility of barbel CYP1A-mRNA expression, but not that of MT-1 or MT-2, as a biomarker in field studies. The tools and protocols developed here are likely to apply to other species of the genus Barbus, with some 700 species distributed throughout most of the Old World." @default.
- W1983036150 created "2016-06-24" @default.
- W1983036150 creator A5003866204 @default.
- W1983036150 creator A5008239541 @default.
- W1983036150 creator A5018688040 @default.
- W1983036150 creator A5024906081 @default.
- W1983036150 creator A5048189317 @default.
- W1983036150 creator A5049041855 @default.
- W1983036150 creator A5081418619 @default.
- W1983036150 creator A5089820365 @default.
- W1983036150 date "2007-04-01" @default.
- W1983036150 modified "2023-10-15" @default.
- W1983036150 title "Environmental monitoring by gene expression biomarkers in Barbus graellsii: Laboratory and field studies" @default.
- W1983036150 cites W1583269539 @default.
- W1983036150 cites W1822518544 @default.
- W1983036150 cites W1965027439 @default.
- W1983036150 cites W1981436807 @default.
- W1983036150 cites W1982604193 @default.
- W1983036150 cites W1982996828 @default.
- W1983036150 cites W1989608172 @default.
- W1983036150 cites W1990452088 @default.
- W1983036150 cites W1996536331 @default.
- W1983036150 cites W2003710683 @default.
- W1983036150 cites W2008724267 @default.
- W1983036150 cites W2016185686 @default.
- W1983036150 cites W2019516976 @default.
- W1983036150 cites W2021943772 @default.
- W1983036150 cites W2022870837 @default.
- W1983036150 cites W2023018832 @default.
- W1983036150 cites W2024784259 @default.
- W1983036150 cites W2030829830 @default.
- W1983036150 cites W2048244792 @default.
- W1983036150 cites W2054202324 @default.
- W1983036150 cites W2059692457 @default.
- W1983036150 cites W2065485117 @default.
- W1983036150 cites W2066568472 @default.
- W1983036150 cites W2067781373 @default.
- W1983036150 cites W2068410381 @default.
- W1983036150 cites W2074608518 @default.
- W1983036150 cites W2087793086 @default.
- W1983036150 cites W2108244474 @default.
- W1983036150 cites W2110871998 @default.
- W1983036150 cites W2120893611 @default.
- W1983036150 cites W2126750976 @default.
- W1983036150 cites W2148795999 @default.
- W1983036150 cites W2161087929 @default.
- W1983036150 cites W2187527765 @default.
- W1983036150 cites W2210297647 @default.
- W1983036150 cites W2239384431 @default.
- W1983036150 cites W4205653323 @default.
- W1983036150 doi "https://doi.org/10.1016/j.chemosphere.2006.11.032" @default.
- W1983036150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17217992" @default.
- W1983036150 hasPublicationYear "2007" @default.
- W1983036150 type Work @default.
- W1983036150 sameAs 1983036150 @default.
- W1983036150 citedByCount "64" @default.
- W1983036150 countsByYear W19830361502012 @default.
- W1983036150 countsByYear W19830361502013 @default.
- W1983036150 countsByYear W19830361502014 @default.
- W1983036150 countsByYear W19830361502015 @default.
- W1983036150 countsByYear W19830361502016 @default.
- W1983036150 countsByYear W19830361502017 @default.
- W1983036150 countsByYear W19830361502018 @default.
- W1983036150 countsByYear W19830361502019 @default.
- W1983036150 countsByYear W19830361502020 @default.
- W1983036150 countsByYear W19830361502022 @default.
- W1983036150 crossrefType "journal-article" @default.
- W1983036150 hasAuthorship W1983036150A5003866204 @default.
- W1983036150 hasAuthorship W1983036150A5008239541 @default.
- W1983036150 hasAuthorship W1983036150A5018688040 @default.
- W1983036150 hasAuthorship W1983036150A5024906081 @default.
- W1983036150 hasAuthorship W1983036150A5048189317 @default.
- W1983036150 hasAuthorship W1983036150A5049041855 @default.
- W1983036150 hasAuthorship W1983036150A5081418619 @default.
- W1983036150 hasAuthorship W1983036150A5089820365 @default.
- W1983036150 hasConcept C104317684 @default.
- W1983036150 hasConcept C150194340 @default.
- W1983036150 hasConcept C161039048 @default.
- W1983036150 hasConcept C18903297 @default.
- W1983036150 hasConcept C199360897 @default.
- W1983036150 hasConcept C20719415 @default.
- W1983036150 hasConcept C2776654248 @default.
- W1983036150 hasConcept C2777095139 @default.
- W1983036150 hasConcept C2777777548 @default.
- W1983036150 hasConcept C2778705729 @default.
- W1983036150 hasConcept C2779814588 @default.
- W1983036150 hasConcept C2909208804 @default.
- W1983036150 hasConcept C41008148 @default.
- W1983036150 hasConcept C505870484 @default.
- W1983036150 hasConcept C54355233 @default.
- W1983036150 hasConcept C86803240 @default.
- W1983036150 hasConcept C90856448 @default.
- W1983036150 hasConceptScore W1983036150C104317684 @default.
- W1983036150 hasConceptScore W1983036150C150194340 @default.
- W1983036150 hasConceptScore W1983036150C161039048 @default.
- W1983036150 hasConceptScore W1983036150C18903297 @default.
- W1983036150 hasConceptScore W1983036150C199360897 @default.
- W1983036150 hasConceptScore W1983036150C20719415 @default.