Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983049515> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1983049515 endingPage "1193" @default.
- W1983049515 startingPage "1187" @default.
- W1983049515 abstract "Isolated lower esophageal sphincter (LES) relaxation, defined as a transient sphincteric relaxation unaccompanied by esophageal peristalsis, has been shown to precede most episodes of gastroesophageal reflux in humans. We studied the genesis of isolated LES relaxation in anesthetized opossums by observing the response of four components of the deglutition reflex (mylohyoid electrical activity, pharyngeal contraction, esophageal peristalsis, and LES relaxation) to pharyngeal tactile stimulation, electrical stimulation of superior laryngeal nerve (SLN) afferents or cervical vagal efferents, and to balloon distention of the esophageal body. A single pharyngeal stroking evoked isolated LES relaxation in 56% of 160 instances. The proportion of isolated relaxations in response to SLN electrical stimulation varied inversely with the stimulus frequency, occurring in 64% of the responses at 5 Hz and 4% of the responses at 30 Hz. A full four-component deglutition sequence was most likely to occur at the higher frequencies of SLN electrical stimulation. Esophageal balloon distention elicited isolated LES relaxations or no response at low distending volumes, whereas at higher volumes LES relaxation and esophageal contraction predominated. Isolated LES relaxation had significantly less magnitude than relaxations accompanied by esophageal contractions. Bilateral cervical vagotomy abolished all LES and esophageal body responses induced by pharyngeal stroking and SLN stimulation, and rendered the esophageal body and LES less responsive to small volumes of distention. Vagal efferent stimulation produced isolated LES relaxation at lower frequency stimulation and LES relaxation with esophageal contractions at higher frequency stimulation. These studies show that isolated LES relaxation represents incomplete expression of either the deglutitive reflex or the peripheral reflex mediating secondary peristalsis." @default.
- W1983049515 created "2016-06-24" @default.
- W1983049515 creator A5062194039 @default.
- W1983049515 creator A5063050623 @default.
- W1983049515 creator A5074493055 @default.
- W1983049515 date "1986-04-01" @default.
- W1983049515 modified "2023-10-18" @default.
- W1983049515 title "Experimental induction of isolated lower esophageal sphincter relaxation in anesthetized opossums." @default.
- W1983049515 cites W1786378864 @default.
- W1983049515 cites W2038438852 @default.
- W1983049515 cites W2086960999 @default.
- W1983049515 cites W2115224075 @default.
- W1983049515 cites W2118202071 @default.
- W1983049515 cites W2124024297 @default.
- W1983049515 cites W2179264078 @default.
- W1983049515 cites W2179861426 @default.
- W1983049515 cites W2257376979 @default.
- W1983049515 cites W2337261040 @default.
- W1983049515 cites W2405162904 @default.
- W1983049515 cites W2437433694 @default.
- W1983049515 cites W2412341949 @default.
- W1983049515 doi "https://doi.org/10.1172/jci112420" @default.
- W1983049515 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/424455" @default.
- W1983049515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3958186" @default.
- W1983049515 hasPublicationYear "1986" @default.
- W1983049515 type Work @default.
- W1983049515 sameAs 1983049515 @default.
- W1983049515 citedByCount "86" @default.
- W1983049515 countsByYear W19830495152012 @default.
- W1983049515 countsByYear W19830495152015 @default.
- W1983049515 countsByYear W19830495152016 @default.
- W1983049515 countsByYear W19830495152017 @default.
- W1983049515 countsByYear W19830495152020 @default.
- W1983049515 countsByYear W19830495152021 @default.
- W1983049515 countsByYear W19830495152022 @default.
- W1983049515 crossrefType "journal-article" @default.
- W1983049515 hasAuthorship W1983049515A5062194039 @default.
- W1983049515 hasAuthorship W1983049515A5063050623 @default.
- W1983049515 hasAuthorship W1983049515A5074493055 @default.
- W1983049515 hasBestOaLocation W19830495151 @default.
- W1983049515 hasConcept C105702510 @default.
- W1983049515 hasConcept C112497637 @default.
- W1983049515 hasConcept C126322002 @default.
- W1983049515 hasConcept C141071460 @default.
- W1983049515 hasConcept C163415756 @default.
- W1983049515 hasConcept C185592680 @default.
- W1983049515 hasConcept C206813253 @default.
- W1983049515 hasConcept C24998067 @default.
- W1983049515 hasConcept C2776029896 @default.
- W1983049515 hasConcept C2776512019 @default.
- W1983049515 hasConcept C2777819096 @default.
- W1983049515 hasConcept C2779263132 @default.
- W1983049515 hasConcept C2992204568 @default.
- W1983049515 hasConcept C42219234 @default.
- W1983049515 hasConcept C71924100 @default.
- W1983049515 hasConcept C83974742 @default.
- W1983049515 hasConceptScore W1983049515C105702510 @default.
- W1983049515 hasConceptScore W1983049515C112497637 @default.
- W1983049515 hasConceptScore W1983049515C126322002 @default.
- W1983049515 hasConceptScore W1983049515C141071460 @default.
- W1983049515 hasConceptScore W1983049515C163415756 @default.
- W1983049515 hasConceptScore W1983049515C185592680 @default.
- W1983049515 hasConceptScore W1983049515C206813253 @default.
- W1983049515 hasConceptScore W1983049515C24998067 @default.
- W1983049515 hasConceptScore W1983049515C2776029896 @default.
- W1983049515 hasConceptScore W1983049515C2776512019 @default.
- W1983049515 hasConceptScore W1983049515C2777819096 @default.
- W1983049515 hasConceptScore W1983049515C2779263132 @default.
- W1983049515 hasConceptScore W1983049515C2992204568 @default.
- W1983049515 hasConceptScore W1983049515C42219234 @default.
- W1983049515 hasConceptScore W1983049515C71924100 @default.
- W1983049515 hasConceptScore W1983049515C83974742 @default.
- W1983049515 hasIssue "4" @default.
- W1983049515 hasLocation W19830495151 @default.
- W1983049515 hasLocation W19830495152 @default.
- W1983049515 hasLocation W19830495153 @default.
- W1983049515 hasLocation W19830495154 @default.
- W1983049515 hasLocation W19830495155 @default.
- W1983049515 hasOpenAccess W1983049515 @default.
- W1983049515 hasPrimaryLocation W19830495151 @default.
- W1983049515 hasRelatedWork W1740736980 @default.
- W1983049515 hasRelatedWork W1980879413 @default.
- W1983049515 hasRelatedWork W1997994982 @default.
- W1983049515 hasRelatedWork W2095316557 @default.
- W1983049515 hasRelatedWork W2152858484 @default.
- W1983049515 hasRelatedWork W2160326497 @default.
- W1983049515 hasRelatedWork W2184911051 @default.
- W1983049515 hasRelatedWork W2312480362 @default.
- W1983049515 hasRelatedWork W2317344054 @default.
- W1983049515 hasRelatedWork W4250161473 @default.
- W1983049515 hasVolume "77" @default.
- W1983049515 isParatext "false" @default.
- W1983049515 isRetracted "false" @default.
- W1983049515 magId "1983049515" @default.
- W1983049515 workType "article" @default.