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- W1983066351 endingPage "384" @default.
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- W1983066351 abstract "Mechanistic information and structure-based design methods have been used to design a series of nonpeptide cyclic ureas that are potent inhibitors of human immunodeficiency virus (HIV) protease and HIV replication. A fundamental feature of these inhibitors is the cyclic urea carbonyl oxygen that mimics the hydrogen-bonding features of a key structural water molecule. The success of the design in both displacing and mimicking the structural water molecule was confirmed by x-ray crystallographic studies. Highly selective, preorganized inhibitors with relatively low molecular weight and high oral bioavailability were synthesized." @default.
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- W1983066351 date "1994-01-21" @default.
- W1983066351 modified "2023-10-16" @default.
- W1983066351 title "Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors" @default.
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- W1983066351 doi "https://doi.org/10.1126/science.8278812" @default.
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