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• W1983086543 abstract "Signaling from small GTPases is a tightly regulated process. In this work we used a protein microarray screen to identify the Rac-specific GAP, ArhGAP15, as a substrate of the Rac effectors Pak1 and Pak2. In addition to serving as a substrate of Pak1/2, we found that ArhGAP15, via its PH domain, bound to these kinases. The association of ArhGAP15 to Pak1/2 resulted in mutual inhibition of GAP and kinase catalytic activity, respectively. Knock-down of ArhGAP15 resulted in activation of Pak1/2, both indirectly, as a result of Rac activation, and directly, as a result of disruption of the ArhGAP15/Pak complex. Our data suggest that ArhGAP15 plays a dual negative role in regulating small GTPase signaling, by acting at the level of the GTPase itself, as well interacting with its effector, Pak kinase." @default.
• W1983086543 created "2016-06-24" @default.
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• W1983086543 date "2013-07-01" @default.
• W1983086543 modified "2023-10-14" @default.
• W1983086543 title "ArhGAP15, a Rac-specific GTPase-activating Protein, Plays a Dual Role in Inhibiting Small GTPase Signaling" @default.
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• W1983086543 doi "https://doi.org/10.1074/jbc.m113.459719" @default.
• W1983086543 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3774378" @default.
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