FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983128247> ?p ?o ?g. }

• W1983128247 endingPage "135" @default.
• W1983128247 startingPage "132" @default.
• W1983128247 abstract "T cell precursors are first detected in the thymus at eight weeks of gestation. By 15 to 20 weeks of gestation, T-cell precursors expressing alpha beta and gamma delta T-cell receptors are present in the thymus in numbers relatively similar to those found in postnatal life. However, recent data suggest that T-cell receptor diversity is more limited during fetal and neonatal life than in adults. Additionally, the functional capacity of T cells in the fetus and neonate is immature, in that neonatal T cells express a limited repertoire of lymphokines in response to activation. Specifically, the production of the lymphokines, interferon-gamma and interleukin-4, which participate in the maturation of cytotoxic cells, activation of macrophages, and the maturation and modulation of B cell function and isotype expression, is reduced more than tenfold compared to cells from adults. This appears to result primarily from the lack of memory T cells in the fetus and neonate, reflecting their antigenic naivete. The difference in lymphokine expression is due to diminished transcription of these genes in neonatal T cells in response to activation. Preliminary data indicate that differences in essential promoter elements regulating transcription of these lymphokine genes plays a role in their differential expression in T cells." @default.
• W1983128247 created "2016-06-24" @default.
• W1983128247 creator A5019413838 @default.
• W1983128247 creator A5022513296 @default.
• W1983128247 creator A5031397502 @default.
• W1983128247 creator A5065207317 @default.
• W1983128247 creator A5066552018 @default.
• W1983128247 date "1992-10-12" @default.
• W1983128247 modified "2023-10-01" @default.
• W1983128247 title "Ontogeny of T Lymphocyte Function in the Neonate" @default.
• W1983128247 cites W1490775039 @default.
• W1983128247 cites W1521285578 @default.
• W1983128247 cites W1543837724 @default.
• W1983128247 cites W1550378267 @default.
• W1983128247 cites W1568059997 @default.
• W1983128247 cites W1597573846 @default.
• W1983128247 cites W1825275804 @default.
• W1983128247 cites W1929194486 @default.
• W1983128247 cites W1983067916 @default.
• W1983128247 cites W2002604831 @default.
• W1983128247 cites W2004640182 @default.
• W1983128247 cites W2021008506 @default.
• W1983128247 cites W202718674 @default.
• W1983128247 cites W2029060163 @default.
• W1983128247 cites W2031011895 @default.
• W1983128247 cites W2052524342 @default.
• W1983128247 cites W2055727922 @default.
• W1983128247 cites W2061519078 @default.
• W1983128247 cites W2068505049 @default.
• W1983128247 cites W2073694401 @default.
• W1983128247 cites W2076889423 @default.
• W1983128247 cites W2083986356 @default.
• W1983128247 cites W2105706890 @default.
• W1983128247 cites W2114765267 @default.
• W1983128247 cites W2139186989 @default.
• W1983128247 cites W2314670345 @default.
• W1983128247 cites W87188239 @default.
• W1983128247 doi "https://doi.org/10.1111/j.1600-0897.1992.tb00774.x" @default.
• W1983128247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1285862" @default.
• W1983128247 hasPublicationYear "1992" @default.
• W1983128247 type Work @default.
• W1983128247 sameAs 1983128247 @default.
• W1983128247 citedByCount "43" @default.
• W1983128247 countsByYear W19831282472012 @default.
• W1983128247 countsByYear W19831282472013 @default.
• W1983128247 countsByYear W19831282472016 @default.
• W1983128247 countsByYear W19831282472017 @default.
• W1983128247 countsByYear W19831282472018 @default.
• W1983128247 countsByYear W19831282472019 @default.
• W1983128247 crossrefType "journal-article" @default.
• W1983128247 hasAuthorship W1983128247A5019413838 @default.
• W1983128247 hasAuthorship W1983128247A5022513296 @default.
• W1983128247 hasAuthorship W1983128247A5031397502 @default.
• W1983128247 hasAuthorship W1983128247A5065207317 @default.
• W1983128247 hasAuthorship W1983128247A5066552018 @default.
• W1983128247 hasConcept C147483822 @default.
• W1983128247 hasConcept C154317977 @default.
• W1983128247 hasConcept C170493617 @default.
• W1983128247 hasConcept C172680121 @default.
• W1983128247 hasConcept C202751555 @default.
• W1983128247 hasConcept C203014093 @default.
• W1983128247 hasConcept C2776090121 @default.
• W1983128247 hasConcept C2777371288 @default.
• W1983128247 hasConcept C2779234561 @default.
• W1983128247 hasConcept C2992881475 @default.
• W1983128247 hasConcept C49382859 @default.
• W1983128247 hasConcept C54355233 @default.
• W1983128247 hasConcept C86803240 @default.
• W1983128247 hasConcept C8891405 @default.
• W1983128247 hasConcept C95444343 @default.
• W1983128247 hasConceptScore W1983128247C147483822 @default.
• W1983128247 hasConceptScore W1983128247C154317977 @default.
• W1983128247 hasConceptScore W1983128247C170493617 @default.
• W1983128247 hasConceptScore W1983128247C172680121 @default.
• W1983128247 hasConceptScore W1983128247C202751555 @default.
• W1983128247 hasConceptScore W1983128247C203014093 @default.
• W1983128247 hasConceptScore W1983128247C2776090121 @default.
• W1983128247 hasConceptScore W1983128247C2777371288 @default.
• W1983128247 hasConceptScore W1983128247C2779234561 @default.
• W1983128247 hasConceptScore W1983128247C2992881475 @default.
• W1983128247 hasConceptScore W1983128247C49382859 @default.
• W1983128247 hasConceptScore W1983128247C54355233 @default.
• W1983128247 hasConceptScore W1983128247C86803240 @default.
• W1983128247 hasConceptScore W1983128247C8891405 @default.
• W1983128247 hasConceptScore W1983128247C95444343 @default.
• W1983128247 hasIssue "3-4" @default.
• W1983128247 hasLocation W19831282471 @default.
• W1983128247 hasLocation W19831282472 @default.
• W1983128247 hasOpenAccess W1983128247 @default.
• W1983128247 hasPrimaryLocation W19831282471 @default.
• W1983128247 hasRelatedWork W1964709257 @default.
• W1983128247 hasRelatedWork W1970958732 @default.
• W1983128247 hasRelatedWork W1994736304 @default.
• W1983128247 hasRelatedWork W2055209622 @default.
• W1983128247 hasRelatedWork W2055727922 @default.
• W1983128247 hasRelatedWork W2060850840 @default.
• W1983128247 hasRelatedWork W2410833002 @default.
• W1983128247 hasRelatedWork W2416174146 @default.

• next