FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983147130> ?p ?o ?g. }

• W1983147130 endingPage "4079" @default.
• W1983147130 startingPage "4065" @default.
• W1983147130 abstract "Dysfunction of basal forebrain cholinergic neurons (BFCNs) is an early pathological hallmark of Alzheimer's disease (AD). Numerous studies have indicated that nerve growth factor (NGF) supports survival and phenotypic differentiation of BFCNs. Consistent with a potential link to AD pathogenesis, TrkA, a NGF receptor, is expressed in cholinergic forebrain neuronal populations including those in BF and striatum, and is markedly reduced in individuals with mild cognitive impairment (MCI) without dementia and early-stage AD. To investigate the role of TrkA in the development, connectivity, and function of the BF cholinergic system and its contribution to AD pathology, we have generated a forebrain-specific conditional TrkA knock-out mouse line. Our findings show a key role for TrkA signaling in establishing the BF cholinergic circuitry through the ERK pathway, and demonstrate that the normal developmental increase of choline acetyltransferase expression becomes critically dependent on TrkA signaling before neuronal connections are established. Moreover, the anatomical and physiological deficits caused by lack of TrkA signaling in BFCNs have selective impact on cognitive activity. These data demonstrate that TrkA loss results in cholinergic BF dysfunction and cognitive decline that is reminiscent of MCI and early AD." @default.
• W1983147130 created "2016-06-24" @default.
• W1983147130 creator A5005276553 @default.
• W1983147130 creator A5016994439 @default.
• W1983147130 creator A5032020402 @default.
• W1983147130 creator A5033052747 @default.
• W1983147130 creator A5054983482 @default.
• W1983147130 creator A5085694146 @default.
• W1983147130 creator A5090718965 @default.
• W1983147130 date "2012-03-21" @default.
• W1983147130 modified "2023-10-15" @default.
• W1983147130 title "TrkA Gene Ablation in Basal Forebrain Results in Dysfunction of the Cholinergic Circuitry" @default.
• W1983147130 cites W1494415215 @default.
• W1983147130 cites W1519847602 @default.
• W1983147130 cites W1609471181 @default.
• W1983147130 cites W1673416974 @default.
• W1983147130 cites W1703928766 @default.
• W1983147130 cites W1930427841 @default.
• W1983147130 cites W1945955617 @default.
• W1983147130 cites W1947231608 @default.
• W1983147130 cites W1966768311 @default.
• W1983147130 cites W1966917600 @default.
• W1983147130 cites W1967887989 @default.
• W1983147130 cites W1969479602 @default.
• W1983147130 cites W1972718612 @default.
• W1983147130 cites W1983454995 @default.
• W1983147130 cites W1984854704 @default.
• W1983147130 cites W1984907449 @default.
• W1983147130 cites W1989755760 @default.
• W1983147130 cites W1995490147 @default.
• W1983147130 cites W1996706295 @default.
• W1983147130 cites W2000791321 @default.
• W1983147130 cites W2011397911 @default.
• W1983147130 cites W2013486109 @default.
• W1983147130 cites W2015628975 @default.
• W1983147130 cites W2015795476 @default.
• W1983147130 cites W2020808135 @default.
• W1983147130 cites W2021097827 @default.
• W1983147130 cites W2021593652 @default.
• W1983147130 cites W2023664289 @default.
• W1983147130 cites W2023796931 @default.
• W1983147130 cites W2026315065 @default.
• W1983147130 cites W2027808558 @default.
• W1983147130 cites W2028725530 @default.
• W1983147130 cites W2030193511 @default.
• W1983147130 cites W2036947369 @default.
• W1983147130 cites W2039812926 @default.
• W1983147130 cites W2039901545 @default.
• W1983147130 cites W2048349699 @default.
• W1983147130 cites W2049259050 @default.
• W1983147130 cites W2050389368 @default.
• W1983147130 cites W2054185368 @default.
• W1983147130 cites W2054961876 @default.
• W1983147130 cites W2066093836 @default.
• W1983147130 cites W2073611916 @default.
• W1983147130 cites W2074744143 @default.
• W1983147130 cites W2077304310 @default.
• W1983147130 cites W2079055832 @default.
• W1983147130 cites W2092862588 @default.
• W1983147130 cites W2097391583 @default.
• W1983147130 cites W2102367498 @default.
• W1983147130 cites W2110159269 @default.
• W1983147130 cites W2111977586 @default.
• W1983147130 cites W2118357539 @default.
• W1983147130 cites W2121799607 @default.
• W1983147130 cites W2132590272 @default.
• W1983147130 cites W2139971720 @default.
• W1983147130 cites W2141714782 @default.
• W1983147130 cites W2150013759 @default.
• W1983147130 cites W2158598336 @default.
• W1983147130 cites W2161760743 @default.
• W1983147130 cites W2163142253 @default.
• W1983147130 cites W2168015727 @default.
• W1983147130 cites W2171934036 @default.
• W1983147130 cites W2330956224 @default.
• W1983147130 doi "https://doi.org/10.1523/jneurosci.6314-11.2012" @default.
• W1983147130 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3403817" @default.
• W1983147130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22442072" @default.
• W1983147130 hasPublicationYear "2012" @default.
• W1983147130 type Work @default.
• W1983147130 sameAs 1983147130 @default.
• W1983147130 citedByCount "83" @default.
• W1983147130 countsByYear W19831471302012 @default.
• W1983147130 countsByYear W19831471302013 @default.
• W1983147130 countsByYear W19831471302014 @default.
• W1983147130 countsByYear W19831471302015 @default.
• W1983147130 countsByYear W19831471302016 @default.
• W1983147130 countsByYear W19831471302017 @default.
• W1983147130 countsByYear W19831471302018 @default.
• W1983147130 countsByYear W19831471302019 @default.
• W1983147130 countsByYear W19831471302020 @default.
• W1983147130 countsByYear W19831471302021 @default.
• W1983147130 countsByYear W19831471302022 @default.
• W1983147130 countsByYear W19831471302023 @default.
• W1983147130 crossrefType "journal-article" @default.
• W1983147130 hasAuthorship W1983147130A5005276553 @default.
• W1983147130 hasAuthorship W1983147130A5016994439 @default.
• W1983147130 hasAuthorship W1983147130A5032020402 @default.

• next