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- W1983163923 abstract "Rifampicin was administered in the drinking water to C3Hf and BALBc mice at three dose levels (0.01, 0.03, and 0.06%) for 60 weeks and to Wistar rats at two dose levels (0.03 and 0.06%) for 104 weeks. After completion of the treatment period, C3Hf and BALBc mice and the rats were observed until 114, 120, and 144 weeks of age, respectively. The treatment had no adverse effects on body growth and survival rate. Various types of tumors were observed in all groups. Statistically significant excesses of hepatomas were found in C3Hf female mice treated with rifampicin and in one control group of BALBc male mice. Also an excess of Harderian gland tumors was observed in one control group of BALBc male mice. No significant differences in tumor incidence were found among the rat groups." @default.
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- W1983163923 date "1978-02-01" @default.
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- W1983163923 title "Carcinogenicity study of rifampicin in mice and rats" @default.
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- W1983163923 doi "https://doi.org/10.1016/0041-008x(78)90009-1" @default.
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