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• W1983170790 abstract "We investigated the nuclear higher order compartmentalization of chromatin according to its replication timing (Ferreira et al. 1997) and the relations of this compartmentalization to chromosome structure and the spatial organization of transcription. Our aim was to provide a comprehensive and integrated view on the relations between chromosome structure and functional nuclear architecture. Using different mammalian cell types, we show that distinct higher order compartments whose DNA displays a specific replication timing are stably maintained during all interphase stages. The organizational principle is clonally inherited. We directly demonstrate the presence of polar chromosome territories that align to build up higher order compartments, as previously suggested (Ferreira et al. 1997). Polar chromosome territories display a specific orientation of early and late replicating subregions that correspond to R- or G/C-bands of mitotic chromosomes. Higher order compartments containing G/C-bands replicating during the second half of the S phase display no transcriptional activity detectable by BrUTP pulse labeling and show no evidence of transcriptional competence. Transcriptionally competent and active chromatin is confined to a coherent compartment within the nuclear interior that comprises early replicating R-band sequences. As a whole, the data provide an integrated view on chromosome structure, nuclear higher order compartmentalization, and their relation to the spatial organization of functional nuclear processes." @default.
• W1983170790 created "2016-06-24" @default.
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• W1983170790 date "1999-09-20" @default.
• W1983170790 modified "2023-09-23" @default.
• W1983170790 title "Nuclear Organization of Mammalian Genomes" @default.
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• W1983170790 cites W1982295124 @default.
• W1983170790 cites W1984731778 @default.
• W1983170790 cites W1992264883 @default.
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• W1983170790 doi "https://doi.org/10.1083/jcb.146.6.1211" @default.
• W1983170790 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2156120" @default.
• W1983170790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10491386" @default.
• W1983170790 hasPublicationYear "1999" @default.
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