FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983174976> ?p ?o ?g. }

• W1983174976 endingPage "4498" @default.
• W1983174976 startingPage "4498" @default.
• W1983174976 abstract "purpose. To examine the clinical progression and innate immune responses during Pseudomonas aeruginosa (PA) keratitis in cathelicidin-deficient (KO) mice. methods. PA (ATCC 19660) keratitis was induced in KO mice and wild-type (WT) littermates generated on a 129/SVJ background. Clinical score and histopathology were used to monitor the progression of infection at postinfection (PI) days 1, 3, 7, 14, and 21. Mouse corneas were harvested for viable bacteria quantitation, and myeloperoxidase (MPO) assays were performed to determine the number of infiltrating neutrophils. ELISA was used to quantitate interleukin (IL)-1β, IL-6, macrophage inflammatory peptide (MIP)-2, keratinocyte-derived chemokine (KC), tumor necrosis factor (TNF)-α, and vascular endothelial growth factor (VEGF) levels in the corneas. results. WT mice were resistant (cornea healed), whereas KO mice showed increased susceptibility (corneas failed to recover by 21 days or perforated) to PA infection. Clinical scores were significantly elevated in the infected corneas of KO mice versus WT mice at 7, 14, and 21 days PI. Absence of cathelicidin resulted in significantly delayed clearance of PA in the cornea and an increased number of infiltrating neutrophils at 1, 3, 7, and 14 days PI. KO mice also exhibited differential expression of protein levels for IL-1β, IL-6, MIP-2, KC, TNF-α, and VEGF up to day 21 PI compared with the WT mice. conclusions. Cathelicidin-deficient mice showed considerable susceptibility to PA keratitis. The present study demonstrates direct in vivo evidence that endogenous expression of cathelicidin provides defense against corneal PA infection indicating its importance in host innate immunity at the ocular surface." @default.
• W1983174976 created "2016-06-24" @default.
• W1983174976 creator A5024601867 @default.
• W1983174976 creator A5055585390 @default.
• W1983174976 creator A5066011023 @default.
• W1983174976 creator A5084515179 @default.
• W1983174976 date "2007-10-01" @default.
• W1983174976 modified "2023-10-16" @default.
• W1983174976 title "Cathelicidin-Deficient (<i>Cnlp</i>⁻^/⁻) Mice Show Increased Susceptibility to<i>Pseudomonas aeruginosa</i>Keratitis" @default.
• W1983174976 cites W1491097392 @default.
• W1983174976 cites W1536674483 @default.
• W1983174976 cites W1578768687 @default.
• W1983174976 cites W1594774706 @default.
• W1983174976 cites W169105841 @default.
• W1983174976 cites W1754273948 @default.
• W1983174976 cites W1840611749 @default.
• W1983174976 cites W1844363986 @default.
• W1983174976 cites W1917885463 @default.
• W1983174976 cites W1921818371 @default.
• W1983174976 cites W1936763432 @default.
• W1983174976 cites W1949132312 @default.
• W1983174976 cites W1964758221 @default.
• W1983174976 cites W1966402088 @default.
• W1983174976 cites W1968931227 @default.
• W1983174976 cites W1986224819 @default.
• W1983174976 cites W1986564074 @default.
• W1983174976 cites W1987399881 @default.
• W1983174976 cites W1988032147 @default.
• W1983174976 cites W1989234621 @default.
• W1983174976 cites W1995519698 @default.
• W1983174976 cites W1997763341 @default.
• W1983174976 cites W1999220050 @default.
• W1983174976 cites W2002498875 @default.
• W1983174976 cites W2003793467 @default.
• W1983174976 cites W2007632666 @default.
• W1983174976 cites W2008058658 @default.
• W1983174976 cites W2009242793 @default.
• W1983174976 cites W2013547825 @default.
• W1983174976 cites W2026263963 @default.
• W1983174976 cites W2026644554 @default.
• W1983174976 cites W2029086903 @default.
• W1983174976 cites W2029790299 @default.
• W1983174976 cites W2034280103 @default.
• W1983174976 cites W2036684468 @default.
• W1983174976 cites W2042116386 @default.
• W1983174976 cites W2043639065 @default.
• W1983174976 cites W2051142131 @default.
• W1983174976 cites W2053044114 @default.
• W1983174976 cites W2058624910 @default.
• W1983174976 cites W2059184072 @default.
• W1983174976 cites W2059361679 @default.
• W1983174976 cites W2060483617 @default.
• W1983174976 cites W2063116767 @default.
• W1983174976 cites W2065361083 @default.
• W1983174976 cites W2067783625 @default.
• W1983174976 cites W2073247904 @default.
• W1983174976 cites W2074456435 @default.
• W1983174976 cites W2078900016 @default.
• W1983174976 cites W2079633128 @default.
• W1983174976 cites W2085793178 @default.
• W1983174976 cites W2087105369 @default.
• W1983174976 cites W2090407536 @default.
• W1983174976 cites W2093748429 @default.
• W1983174976 cites W2093934354 @default.
• W1983174976 cites W2094511397 @default.
• W1983174976 cites W2106026809 @default.
• W1983174976 cites W2117618216 @default.
• W1983174976 cites W2121143282 @default.
• W1983174976 cites W2125051590 @default.
• W1983174976 cites W2125861612 @default.
• W1983174976 cites W2125935614 @default.
• W1983174976 cites W2126516803 @default.
• W1983174976 cites W2130038503 @default.
• W1983174976 cites W2130212783 @default.
• W1983174976 cites W2139212892 @default.
• W1983174976 cites W2139615718 @default.
• W1983174976 cites W2142461098 @default.
• W1983174976 cites W2146750081 @default.
• W1983174976 cites W2155287267 @default.
• W1983174976 cites W2157252835 @default.
• W1983174976 cites W2165069088 @default.
• W1983174976 cites W2166357414 @default.
• W1983174976 cites W2169759699 @default.
• W1983174976 cites W2582398023 @default.
• W1983174976 cites W48086618 @default.
• W1983174976 cites W69272294 @default.
• W1983174976 cites W2144719052 @default.
• W1983174976 doi "https://doi.org/10.1167/iovs.07-0274" @default.
• W1983174976 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4234056" @default.
• W1983174976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17898271" @default.
• W1983174976 hasPublicationYear "2007" @default.
• W1983174976 type Work @default.
• W1983174976 sameAs 1983174976 @default.
• W1983174976 citedByCount "98" @default.
• W1983174976 countsByYear W19831749762012 @default.
• W1983174976 countsByYear W19831749762013 @default.
• W1983174976 countsByYear W19831749762014 @default.
• W1983174976 countsByYear W19831749762015 @default.

• next