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• W1983180570 startingPage "1867" @default.
• W1983180570 abstract "Par-4 is a tumor suppressor protein with a pro-apoptotic function. Epigenetic silencing of Par-4 is seen in diverse tumors and Par-4 knockout mice develop spontaneous tumors in various tissues. Endogenous Par-4 is essential for sensitization of cells to diverse apoptotic stimuli, whereas ectopic expression of Par-4 can selectively induce apoptosis in cancer cells. The cancer-specific pro-apoptotic action of Par-4 resides in its centrally located SAC domain. This review emphasizes the role of Par-4/SAC in apoptosis and tumor resistance. SAC transgenic mice display normal development and life span, and, most importantly, are resistant to spontaneous, as well as oncogene-induced, autochthonous tumors. The tumor resistant phenotype and undetectable toxicity of SAC in vivo suggests the SAC domain possesses tremendous therapeutic potential." @default.
• W1983180570 created "2016-06-24" @default.
• W1983180570 creator A5074300281 @default.
• W1983180570 creator A5074581426 @default.
• W1983180570 date "2008-12-01" @default.
• W1983180570 modified "2023-10-01" @default.
• W1983180570 title "Apoptosis and tumor resistance conferred by Par-4" @default.
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• W1983180570 doi "https://doi.org/10.4161/cbt.7.12.6945" @default.
• W1983180570 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2683365" @default.
• W1983180570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18836307" @default.
• W1983180570 hasPublicationYear "2008" @default.
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