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- W1983181908 abstract "T1 glottic cancer is highly curable with definitive RT. Traditional radiation techniques result in high radiation doses to the carotid arteries that accelerates atherosclerosis, and increases the risk for ischemic stroke in a dose-dependent fashion. We review our clinical outcomes for T1 larynx cancer patients treated with IMRT. Dosimetric in silico comparisons were performed between virtual conventional opposed lateral and delivered IMRT plans in terms of dosimetric correlates for RT sequelae. Twenty-eight patients with T1 glottic cancer were treated with IMRT. Non-target structures, including left and right carotid arteries, middle pharyngeal constrictor (MPC), and inferior pharyngeal constrictor (IPC) were contoured. We then evaluated plans using generalized equivalent uniform dose and dose-volume parameters. Mean prescription dose was 63.93 +/- 1.69 Gy given over 29 +/- 2 fractions. Median follow-up time after radiation therapy was 20.27 months. There were two local recurrences at 4 and 12 months post-radiation therapy. One patient underwent a salvage larynx preservation surgery, and the other underwent a salvage partial laryngectomy. Both had no evidence of disease at last follow-up. We were able to achieve a mean carotid V35 and V50 of 8% and 3% respectively. The IPC in our patients received a mean dose of 61.57 Gy, and the MPC 24.2 Gy. The generalized effective uniform dose of the carotid arteries ranged from 2.55-14.77 Gy. IMRT significantly reduces carotid artery RT dose without compromising tumor control. The dose to the MPC was also significantly lower with IMRT, but due to the location of the IPC, sparing may affect CTV coverage. The use of IMRT for early glottic cancer may offer benefits, however longer follow-up is needed for confirmation." @default.
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- W1983181908 date "2013-10-01" @default.
- W1983181908 modified "2023-09-27" @default.
- W1983181908 title "Intensity Modulated Radiation Therapy for T1 Glottic Cancer: Initial Clinical Outcomes" @default.
- W1983181908 doi "https://doi.org/10.1016/j.ijrobp.2013.06.1198" @default.
- W1983181908 hasPublicationYear "2013" @default.
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