FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983185770> ?p ?o ?g. }

• W1983185770 endingPage "878" @default.
• W1983185770 startingPage "871" @default.
• W1983185770 abstract "Enhanced production of receptor activator of nuclear factor-kappaB ligand (RANKL) and its binding to RANK on the osteoclasts have been associated with osteolysis in breast cancer bone metastasis. Osteoprotegerin (OPG) is a decoy receptor that prevents RANKL-RANK interaction. This study determined the effects of sustained expression of OPG using a recombinant adeno-associated viral (rAAV) vector in mouse model of osteolytic breast cancer. Bone metastasis was established by intracardiac injection of the human breast cancer cell line MDA-MB-435. Following this, mice were administered a one-time intramuscular injection of rAAV encoding either OPG.Fc (OPG) or green fluorescent protein (GFP). Mice were killed 1 month later and the effects of therapy on tumor growth and bone remodeling were evaluated. Bioluminescence imaging showed significant reduction of tumor growth in bone of OPG.Fc-treated mice. Micro-computed tomography (microCT) analysis and histomorphometry of the tibia indicated significant protection of trabecular and cortical bones after OPG.Fc therapy. Despite the prevention of bone loss and tumor growth in bone, OPG.Fc therapy failed to provide long-term survival. OPG.Fc-treated mice developed more bone than age-matched normal mice, indicating a requirement for regulated transgene expression. Results of this study indicate the potential of rAAV-OPG therapy for reducing morbidity and mortality in breast cancer patients with osteolytic bone damage." @default.
• W1983185770 created "2016-06-24" @default.
• W1983185770 creator A5001932028 @default.
• W1983185770 creator A5002305391 @default.
• W1983185770 creator A5007729549 @default.
• W1983185770 creator A5017208495 @default.
• W1983185770 creator A5017420879 @default.
• W1983185770 creator A5040167645 @default.
• W1983185770 creator A5080151888 @default.
• W1983185770 creator A5082575962 @default.
• W1983185770 date "2008-05-01" @default.
• W1983185770 modified "2023-10-16" @default.
• W1983185770 title "Systemic Osteoprotegerin Gene Therapy Restores Tumor-induced Bone Loss in a Therapeutic Model of Breast Cancer Bone Metastasis" @default.
• W1983185770 cites W1965734230 @default.
• W1983185770 cites W1966970126 @default.
• W1983185770 cites W1985148995 @default.
• W1983185770 cites W1986310612 @default.
• W1983185770 cites W1989046476 @default.
• W1983185770 cites W1989526399 @default.
• W1983185770 cites W1994001076 @default.
• W1983185770 cites W1997829755 @default.
• W1983185770 cites W2000647744 @default.
• W1983185770 cites W2015433718 @default.
• W1983185770 cites W2016032078 @default.
• W1983185770 cites W2021505980 @default.
• W1983185770 cites W2039719308 @default.
• W1983185770 cites W2051159468 @default.
• W1983185770 cites W2051255001 @default.
• W1983185770 cites W2051528631 @default.
• W1983185770 cites W2059309033 @default.
• W1983185770 cites W2067076724 @default.
• W1983185770 cites W2072772987 @default.
• W1983185770 cites W2074494405 @default.
• W1983185770 cites W2082927803 @default.
• W1983185770 cites W2086008590 @default.
• W1983185770 cites W2102969047 @default.
• W1983185770 cites W2108706718 @default.
• W1983185770 cites W2111967805 @default.
• W1983185770 cites W2114844287 @default.
• W1983185770 cites W2127360580 @default.
• W1983185770 cites W2143321740 @default.
• W1983185770 cites W2150265325 @default.
• W1983185770 cites W2169167250 @default.
• W1983185770 doi "https://doi.org/10.1038/mt.2008.48" @default.
• W1983185770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18388919" @default.
• W1983185770 hasPublicationYear "2008" @default.
• W1983185770 type Work @default.
• W1983185770 sameAs 1983185770 @default.
• W1983185770 citedByCount "29" @default.
• W1983185770 countsByYear W19831857702012 @default.
• W1983185770 countsByYear W19831857702013 @default.
• W1983185770 countsByYear W19831857702014 @default.
• W1983185770 countsByYear W19831857702015 @default.
• W1983185770 countsByYear W19831857702016 @default.
• W1983185770 countsByYear W19831857702018 @default.
• W1983185770 countsByYear W19831857702019 @default.
• W1983185770 countsByYear W19831857702022 @default.
• W1983185770 crossrefType "journal-article" @default.
• W1983185770 hasAuthorship W1983185770A5001932028 @default.
• W1983185770 hasAuthorship W1983185770A5002305391 @default.
• W1983185770 hasAuthorship W1983185770A5007729549 @default.
• W1983185770 hasAuthorship W1983185770A5017208495 @default.
• W1983185770 hasAuthorship W1983185770A5017420879 @default.
• W1983185770 hasAuthorship W1983185770A5040167645 @default.
• W1983185770 hasAuthorship W1983185770A5080151888 @default.
• W1983185770 hasAuthorship W1983185770A5082575962 @default.
• W1983185770 hasBestOaLocation W19831857701 @default.
• W1983185770 hasConcept C104317684 @default.
• W1983185770 hasConcept C111335760 @default.
• W1983185770 hasConcept C111599444 @default.
• W1983185770 hasConcept C121608353 @default.
• W1983185770 hasConcept C126322002 @default.
• W1983185770 hasConcept C134018914 @default.
• W1983185770 hasConcept C141071460 @default.
• W1983185770 hasConcept C143998085 @default.
• W1983185770 hasConcept C161997846 @default.
• W1983185770 hasConcept C170033053 @default.
• W1983185770 hasConcept C170493617 @default.
• W1983185770 hasConcept C2775930923 @default.
• W1983185770 hasConcept C2777783956 @default.
• W1983185770 hasConcept C2779013556 @default.
• W1983185770 hasConcept C2779428903 @default.
• W1983185770 hasConcept C2780426850 @default.
• W1983185770 hasConcept C2781282405 @default.
• W1983185770 hasConcept C502942594 @default.
• W1983185770 hasConcept C530470458 @default.
• W1983185770 hasConcept C54009773 @default.
• W1983185770 hasConcept C54355233 @default.
• W1983185770 hasConcept C55493867 @default.
• W1983185770 hasConcept C71924100 @default.
• W1983185770 hasConcept C81885089 @default.
• W1983185770 hasConcept C86803240 @default.
• W1983185770 hasConcept C88045685 @default.
• W1983185770 hasConceptScore W1983185770C104317684 @default.
• W1983185770 hasConceptScore W1983185770C111335760 @default.
• W1983185770 hasConceptScore W1983185770C111599444 @default.
• W1983185770 hasConceptScore W1983185770C121608353 @default.
• W1983185770 hasConceptScore W1983185770C126322002 @default.

• next