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- W1983204865 abstract "Pinpointing genes involved in non-right-handedness has the potential to clarify developmental contributions to human brain lateralization. Major-gene models have been considered for human handedness which allow for phenocopy and reduced penetrance, i.e. an imperfect correspondence between genotype and phenotype. However, a recent genome-wide association scan did not detect any common polymorphisms with substantial genetic effects. Previous linkage studies in families have also not yielded significant findings. Genetic heterogeneity and/or polygenicity are therefore indicated, but it remains possible that relatively rare, or even unique, major-genetic effects may be detectable in certain extended families with many non-right-handed members. Here we applied whole exome sequencing to 17 members from a single, large consanguineous family from Pakistan. Multipoint linkage analysis across all autosomes did not yield clear candidate genomic regions for involvement in the trait and single-point analysis of exomic variation did not yield clear candidate mutations/genes. Any genetic contribution to handedness in this unusual family is therefore likely to have a complex etiology, as at the population level." @default.
- W1983204865 created "2016-06-24" @default.
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- W1983204865 date "2014-09-01" @default.
- W1983204865 modified "2023-09-25" @default.
- W1983204865 title "Use of imaging technologies in birth defects research, a clinical perspective" @default.
- W1983204865 doi "https://doi.org/10.1016/j.reprotox.2014.07.010" @default.
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