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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983205909> ?p ?o ?g. }

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• W1983205909 abstract "Impaired immune responses occur frequently in cancer patients or in tumor-bearing mice, but the mechanisms of the tumor-induced immune defects remain poorly understood. In an in vivo murine colon carcinoma model (MCA-38), animals bearing a tumor longer than 26 days develop CD8+ T cells with impaired cytotoxic function, decreased expression of the tumor necrosis factor-alpha and granzyme B genes, and decreased ability to mediate an antitumor response in vivo. T lymphocytes from tumor-bearing mice expressed T cell antigen receptors that contained low amounts of CD3 gamma and completely lacked CD3 zeta, which was replaced by the Fc epsilon gamma-chain. Expression of the tyrosine kinases p56lck and p59fyn was also reduced. These changes could be the basis of immune defects in tumor-bearing hosts." @default.
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• W1983205909 date "1992-12-11" @default.
• W1983205909 modified "2023-10-16" @default.
• W1983205909 title "Alterations in Signal Transduction Molecules in T Lymphocytes from Tumor-Bearing Mice" @default.
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• W1983205909 doi "https://doi.org/10.1126/science.1465616" @default.
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