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- W1983206838 endingPage "e103987" @default.
- W1983206838 startingPage "e103987" @default.
- W1983206838 abstract "MicroRNAs (miRNAs) are endogenous small non-coding RNAs that have a pivotal role in the post-transcriptional regulation of gene expression and their misregulation is common in different types of cancer. Although it has been shown that miR-7 plays an oncogenic role in different cellular contexts, the molecular mechanisms by which miR-7 promotes cell transformation are not well understood. Here we show that the transcription factor KLF4 is a direct target of miR-7 and present experimental evidence indicating that the regulation of KLF4 by miR-7 has functional implications in epithelial cell transformation. Stable overexpression of miR-7 into lung and skin epithelial cells enhanced cell proliferation, cell migration and tumor formation. Alteration of these cellular functions by miR-7 resulted from misregulation of KLF4 target genes involved in cell cycle control. miR-7-induced tumors showed decreased p21 and increased Cyclin D levels. Taken together, these findings indicate that miR-7 acts as an oncomiR in epithelial cells in part by directly regulating KLF4 expression. Thus, we conclude that miR-7 acts as an oncomiR in the epithelial cellular context, where through the negative regulation of KLF4-dependent signaling pathways, miR-7 promotes cellular transformation and tumor growth." @default.
- W1983206838 created "2016-06-24" @default.
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- W1983206838 creator A5026604963 @default.
- W1983206838 creator A5083129948 @default.
- W1983206838 date "2014-09-02" @default.
- W1983206838 modified "2023-10-18" @default.
- W1983206838 title "MiR-7 Promotes Epithelial Cell Transformation by Targeting the Tumor Suppressor KLF4" @default.
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- W1983206838 doi "https://doi.org/10.1371/journal.pone.0103987" @default.
- W1983206838 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4151986" @default.
- W1983206838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25181544" @default.
- W1983206838 hasPublicationYear "2014" @default.
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