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- W1983207968 abstract "The effect of Cl−, HCO3−, Br−, acetazolamide, thiocyanate and amiloride on urine formation in Locusta migratoria Malpighian tubules have been determined. The rate of fluid secretion depends markedly on the concentration of Cl− in the bathing solution with concentrations less than 90 mM resulting in reduced fluid secretion. Substitution of Br− for Cl− had no significant effect on the rate of the fluid secretion. Replacement of NaHCO3 with NaCl in Hepes buffered Ringer solution reduced the rate of urine production by 23%. Fluid secretions were reduced in the presence of 10−4–10−2 M acetazolamide, a carbonic anhydrase inhibitor. The combined effect of acetazolamide in the absence of HCO3− appears to be additive. A 1 mM concentration of thiocyanate, an ionic inhibitor, reduced fluid secretion by 35%. Amiloride interferes with the electrogenic entry of Na+ into the cell and a 1 mM solution reduced fluid secretion by 94% with secretion completely inhibited in 80% of the tubules tested." @default.
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- W1983207968 date "1994-12-01" @default.
- W1983207968 modified "2023-09-23" @default.
- W1983207968 title "Effects of anions, acetazolamide, thiocyanate and amiloride on fluid secretion by the Malpighian tubules of Locusta migratoria L." @default.
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- W1983207968 doi "https://doi.org/10.1016/0022-1910(94)90062-0" @default.
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