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• W1983216462 abstract "Astrocytes respond to environmental cues and play a multifaceted role in the response to trauma in the central nervous system. As the most prevalent contributors to the glial scar, astrocytes are targeted as barriers to regeneration. However, there is also strong evidence that astrocytes are vital for neuroprotection and metabolic support after injury. In addition, consistent with their role during development, astrocytes may be capable of supporting the growth of injured axons. Therefore, we hypothesized that with appropriate stimulation, the reparative functions of endogenous astrocytes could be harnessed to promote axon growth and recovery after spinal cord injury. Transforming growth factor-alpha (TGF-alpha) is a mitogenic growth factor that is active on astrocytes and is poised to contribute to such a strategy. Recombinant TGF-alpha was administered intrathecally to adult C57BL/6 mice for two weeks following a moderate mid-thoracic spinal cord contusion. By three weeks post-injury, TGF-alpha infusion had not affected locomotor recovery, but promoted extensive axon growth and altered the composition of the lesion site. The center of the lesion in the treated mice contained greater numbers of new cells and increased astrocyte invasion. Despite the expression of inhibitory proteoglycans, there was a marked increase in axons expressing neurofilament and GAP-43 immunoreactivity, and the new axons were closely associated with increased laminin expression within and beyond the astrocyte matrix. The results demonstrate that astrocytes are dynamic players in the response to spinal cord injury, and the growth-supportive role of these cells can be enhanced by TGF-alpha infusion." @default.
• W1983216462 created "2016-06-24" @default.
• W1983216462 creator A5030344996 @default.
• W1983216462 creator A5044977008 @default.
• W1983216462 creator A5087284633 @default.
• W1983216462 date "2008-11-01" @default.
• W1983216462 modified "2023-10-01" @default.
• W1983216462 title "TGF-α increases astrocyte invasion and promotes axonal growth into the lesion following spinal cord injury in mice" @default.
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• W1983216462 doi "https://doi.org/10.1016/j.expneurol.2008.06.012" @default.
• W1983216462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2895965" @default.
• W1983216462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18647603" @default.
• W1983216462 hasPublicationYear "2008" @default.
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