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• W1983226093 startingPage "167" @default.
• W1983226093 abstract "Populations of embryonic mouse fibroblasts undergo 10±2 doublings in vitro prior to cessation of growth. We have studied various properties of the DNA of such cells as they undergo this process of in vitro ageing. Following a 1-h pulse with [3H]thymidine the labelling of growing cell populations decreases progressively with serial subcultivation. At early passage levels, the decrease in labelling between passages is rapid, but after about five passages the decline is much slower. Following a long pulse with [3H]thymidine (up to 4 days), up to 50% of the cells in the final passage become labelled. The binding of [3H]actinomycin to nuclei decreases progressively during serial subcultivation. Under conditions of quiescence, induced by serum deprivation, the cells withdraw from the S-phase. Feulgen cytophotometry reveals a wide spectrum of cellular DNA contents in terminal cultures, with 38% of cells possessing more DNA than equivalent early passage cells. Under these conditions, 40% of the fibroblasts bind less actinomycin than any early passage cells. Neither variations in DNA amount nor differences in cell-cycle phases can explain these alterations, which are thought to be related to age-dependent changes in chromatin condensation." @default.
• W1983226093 created "2016-06-24" @default.
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• W1983226093 creator A5075633844 @default.
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• W1983226093 date "1983-06-01" @default.
• W1983226093 modified "2023-09-25" @default.
• W1983226093 title "Replicative activity and actinomycin binding in mouse diploid fibroblasts (in vitro ageing)" @default.
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• W1983226093 doi "https://doi.org/10.1016/0047-6374(83)90110-0" @default.
• W1983226093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6632991" @default.
• W1983226093 hasPublicationYear "1983" @default.
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