FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983227292> ?p ?o ?g. }

• W1983227292 endingPage "3113" @default.
• W1983227292 startingPage "3105" @default.
• W1983227292 abstract "Abstract Because of their frequent expression in a wide spectrum of malignant tumors but not in normal tissue except testis, cancer testis antigens are promising targets. However, except for HOM-TES-14/SCP1, their expression in malignant lymphomas is rare. SCP1 (synaptonemal complex protein 1) has been shown to elicit antibody responses in the autologous host, but no T-cell responses against HOM-TES-14/SCP1 have been reported. Using the SYFPEITHI algorithm, we selected peptides with a high binding affinity to major histocompatibility complex class 2 (MHC 2) molecules. The pentadecamer epitope p635-649 induced specific CD4+ T-cell responses that were shown to be restricted by HLA-DRB1*1401. The responses could be blocked by preincubation of T cells with anti-CD4 and antigen-presenting cells with anti–HLA-DR, respectively, proving the HLA-DR–restricted presentation of p635-649 and a CD4+ T-cell–mediated effector response. Responding CD4+ cells did not secrete interleukin-5 (IL-5), indicating that they belong to the TH1 subtype. The natural processing and presentation of p635-649 were demonstrated by pulsing autologous and allogeneic dendritic cells with a protein fragment covering p635-649. Thus, p635-649 is the first HOM-TES-14/SCP1–derived epitope to fulfill all prerequisites for use as a peptide vaccine in patients with HOM-TES-14/SCP1–expressing tumors, which is the case in two thirds of peripheral T-cell lymphomas." @default.
• W1983227292 created "2016-06-24" @default.
• W1983227292 creator A5012626247 @default.
• W1983227292 creator A5023989937 @default.
• W1983227292 creator A5030025370 @default.
• W1983227292 creator A5061189766 @default.
• W1983227292 creator A5062507836 @default.
• W1983227292 creator A5073053476 @default.
• W1983227292 creator A5075223532 @default.
• W1983227292 date "2005-11-01" @default.
• W1983227292 modified "2023-10-16" @default.
• W1983227292 title "Identification of an epitope derived from the cancer testis antigen HOM-TES-14/SCP1 and presented by dendritic cells to circulating CD4+ T cells" @default.
• W1983227292 cites W1519501426 @default.
• W1983227292 cites W1594179287 @default.
• W1983227292 cites W177504901 @default.
• W1983227292 cites W1870550894 @default.
• W1983227292 cites W1894683288 @default.
• W1983227292 cites W1970395545 @default.
• W1983227292 cites W1981480494 @default.
• W1983227292 cites W1982021681 @default.
• W1983227292 cites W1982752226 @default.
• W1983227292 cites W1984408583 @default.
• W1983227292 cites W1994048581 @default.
• W1983227292 cites W2005984360 @default.
• W1983227292 cites W2006987944 @default.
• W1983227292 cites W2007749743 @default.
• W1983227292 cites W2014122529 @default.
• W1983227292 cites W2025109886 @default.
• W1983227292 cites W2026082376 @default.
• W1983227292 cites W2028852768 @default.
• W1983227292 cites W2029995825 @default.
• W1983227292 cites W2030317951 @default.
• W1983227292 cites W2034982156 @default.
• W1983227292 cites W2036392773 @default.
• W1983227292 cites W2042174530 @default.
• W1983227292 cites W2042400737 @default.
• W1983227292 cites W2044215567 @default.
• W1983227292 cites W2054985048 @default.
• W1983227292 cites W2063366670 @default.
• W1983227292 cites W2081765214 @default.
• W1983227292 cites W2082628257 @default.
• W1983227292 cites W2086147526 @default.
• W1983227292 cites W2095280437 @default.
• W1983227292 cites W2096385955 @default.
• W1983227292 cites W2098988128 @default.
• W1983227292 cites W2106859466 @default.
• W1983227292 cites W2107201675 @default.
• W1983227292 cites W2115323542 @default.
• W1983227292 cites W2130457238 @default.
• W1983227292 cites W2139894578 @default.
• W1983227292 cites W2141543852 @default.
• W1983227292 cites W2144241744 @default.
• W1983227292 cites W2147345889 @default.
• W1983227292 cites W2148564980 @default.
• W1983227292 cites W2155362903 @default.
• W1983227292 cites W2158154689 @default.
• W1983227292 cites W2165142928 @default.
• W1983227292 cites W2167991773 @default.
• W1983227292 cites W2171986697 @default.
• W1983227292 cites W2302140131 @default.
• W1983227292 cites W4254388603 @default.
• W1983227292 doi "https://doi.org/10.1182/blood-2005-04-1487" @default.
• W1983227292 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16030183" @default.
• W1983227292 hasPublicationYear "2005" @default.
• W1983227292 type Work @default.
• W1983227292 sameAs 1983227292 @default.
• W1983227292 citedByCount "33" @default.
• W1983227292 countsByYear W19832272922012 @default.
• W1983227292 countsByYear W19832272922013 @default.
• W1983227292 countsByYear W19832272922014 @default.
• W1983227292 countsByYear W19832272922015 @default.
• W1983227292 countsByYear W19832272922016 @default.
• W1983227292 countsByYear W19832272922018 @default.
• W1983227292 countsByYear W19832272922019 @default.
• W1983227292 countsByYear W19832272922020 @default.
• W1983227292 countsByYear W19832272922021 @default.
• W1983227292 countsByYear W19832272922022 @default.
• W1983227292 countsByYear W19832272922023 @default.
• W1983227292 crossrefType "journal-article" @default.
• W1983227292 hasAuthorship W1983227292A5012626247 @default.
• W1983227292 hasAuthorship W1983227292A5023989937 @default.
• W1983227292 hasAuthorship W1983227292A5030025370 @default.
• W1983227292 hasAuthorship W1983227292A5061189766 @default.
• W1983227292 hasAuthorship W1983227292A5062507836 @default.
• W1983227292 hasAuthorship W1983227292A5073053476 @default.
• W1983227292 hasAuthorship W1983227292A5075223532 @default.
• W1983227292 hasBestOaLocation W19832272921 @default.
• W1983227292 hasConcept C147483822 @default.
• W1983227292 hasConcept C153911025 @default.
• W1983227292 hasConcept C195616568 @default.
• W1983227292 hasConcept C203014093 @default.
• W1983227292 hasConcept C207936829 @default.
• W1983227292 hasConcept C2776090121 @default.
• W1983227292 hasConcept C2778814158 @default.
• W1983227292 hasConcept C67662055 @default.
• W1983227292 hasConcept C83464605 @default.
• W1983227292 hasConcept C86803240 @default.
• W1983227292 hasConcept C8891405 @default.

• next