FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983232753> ?p ?o ?g. }

• W1983232753 endingPage "2992" @default.
• W1983232753 startingPage "2985" @default.
• W1983232753 abstract "Analysis of the ontogeny and localization of the amino (N)-terminal and carboxy (C)-terminal cleavage products of Müllerian Inhibiting Substance (MIS) and their modulation by hormones of the hypothalamic-pituitary gonadal axis by immunohistochemistry and Northern analysis led to the discovery of a novel mode of posttranslational regulation of this differentiating agent. Antibody to both holo- and C-terminal MIS identically stained the cytosol of testicular Sertoli cells from 21-day fetal rats, whereas staining of antibody to N-terminal MIS localized to the basement membrane of seminiferous tubules. In addition, when studied longitudinally, basement membrane staining for N-terminal MIS persisted; cytosolic staining for C-terminal MIS was no longer detectable in post-natal testes, but marked basement membrane staining for the N-terminal fragment could still be observed in the testes of untreated 7-day postnatal animals. When 19-day fetuses were injected with FSH, testes collected 2 days later showed less immunohistochemical staining for holo-, N-, and C-terminal MIS, and less MIS messenger RNA. This suggested that FSH downregulates MIS transcription, as had been shown previously in neonatal testes treated with FSH. Testes collected at 21 days from fetuses treated at day 19 in utero with human CG or testosterone, also showed less staining for holo-MIS, but, surprisingly, increased staining for the N- and C-terminal fragments. These changes in MIS protein were accompanied by no or minimal changes in MIS messenger RNA levels, indicating that human CG and testosterone do not affect transcription, but may regulate the cleavage and/or dissociation of MIS. This study describes a form of post-translational regulation of MIS and shows that both transcription and processing of MIS may be differentially modulated by gonadotropins and sex steroids." @default.
• W1983232753 created "2016-06-24" @default.
• W1983232753 creator A5007227378 @default.
• W1983232753 creator A5015776672 @default.
• W1983232753 creator A5017078013 @default.
• W1983232753 creator A5020129216 @default.
• W1983232753 creator A5084693578 @default.
• W1983232753 date "1991-12-01" @default.
• W1983232753 modified "2023-09-23" @default.
• W1983232753 title "Müllerian Inhibiting Substance Production and Cleavage is Modulated by Gonadotropins and Steroids*" @default.
• W1983232753 cites W1481497040 @default.
• W1983232753 cites W1936821077 @default.
• W1983232753 cites W195758042 @default.
• W1983232753 cites W1975562880 @default.
• W1983232753 cites W1979877257 @default.
• W1983232753 cites W1986469118 @default.
• W1983232753 cites W1987568997 @default.
• W1983232753 cites W1995967812 @default.
• W1983232753 cites W2008570049 @default.
• W1983232753 cites W2009724193 @default.
• W1983232753 cites W2012098560 @default.
• W1983232753 cites W2023540540 @default.
• W1983232753 cites W2026489579 @default.
• W1983232753 cites W2040988043 @default.
• W1983232753 cites W2041736756 @default.
• W1983232753 cites W2049382364 @default.
• W1983232753 cites W2050620572 @default.
• W1983232753 cites W2059665365 @default.
• W1983232753 cites W2060333964 @default.
• W1983232753 cites W2060889469 @default.
• W1983232753 cites W2073249419 @default.
• W1983232753 cites W2073668107 @default.
• W1983232753 cites W2080493727 @default.
• W1983232753 cites W2081689397 @default.
• W1983232753 cites W2088286225 @default.
• W1983232753 cites W2089543118 @default.
• W1983232753 cites W2117507292 @default.
• W1983232753 cites W2135877655 @default.
• W1983232753 cites W2162118744 @default.
• W1983232753 cites W2166037649 @default.
• W1983232753 cites W2170395027 @default.
• W1983232753 cites W2170411999 @default.
• W1983232753 cites W62746391 @default.
• W1983232753 cites W2070875479 @default.
• W1983232753 doi "https://doi.org/10.1210/endo-129-6-2985" @default.
• W1983232753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1954882" @default.
• W1983232753 hasPublicationYear "1991" @default.
• W1983232753 type Work @default.
• W1983232753 sameAs 1983232753 @default.
• W1983232753 citedByCount "41" @default.
• W1983232753 countsByYear W19832327532012 @default.
• W1983232753 countsByYear W19832327532013 @default.
• W1983232753 countsByYear W19832327532014 @default.
• W1983232753 countsByYear W19832327532018 @default.
• W1983232753 countsByYear W19832327532021 @default.
• W1983232753 crossrefType "journal-article" @default.
• W1983232753 hasAuthorship W1983232753A5007227378 @default.
• W1983232753 hasAuthorship W1983232753A5015776672 @default.
• W1983232753 hasAuthorship W1983232753A5017078013 @default.
• W1983232753 hasAuthorship W1983232753A5020129216 @default.
• W1983232753 hasAuthorship W1983232753A5084693578 @default.
• W1983232753 hasConcept C104317684 @default.
• W1983232753 hasConcept C105580179 @default.
• W1983232753 hasConcept C123765429 @default.
• W1983232753 hasConcept C126322002 @default.
• W1983232753 hasConcept C134018914 @default.
• W1983232753 hasConcept C203014093 @default.
• W1983232753 hasConcept C204232928 @default.
• W1983232753 hasConcept C2776193487 @default.
• W1983232753 hasConcept C2779066085 @default.
• W1983232753 hasConcept C2781068068 @default.
• W1983232753 hasConcept C54355233 @default.
• W1983232753 hasConcept C55493867 @default.
• W1983232753 hasConcept C71315377 @default.
• W1983232753 hasConcept C71924100 @default.
• W1983232753 hasConcept C74864618 @default.
• W1983232753 hasConcept C86803240 @default.
• W1983232753 hasConcept C95444343 @default.
• W1983232753 hasConceptScore W1983232753C104317684 @default.
• W1983232753 hasConceptScore W1983232753C105580179 @default.
• W1983232753 hasConceptScore W1983232753C123765429 @default.
• W1983232753 hasConceptScore W1983232753C126322002 @default.
• W1983232753 hasConceptScore W1983232753C134018914 @default.
• W1983232753 hasConceptScore W1983232753C203014093 @default.
• W1983232753 hasConceptScore W1983232753C204232928 @default.
• W1983232753 hasConceptScore W1983232753C2776193487 @default.
• W1983232753 hasConceptScore W1983232753C2779066085 @default.
• W1983232753 hasConceptScore W1983232753C2781068068 @default.
• W1983232753 hasConceptScore W1983232753C54355233 @default.
• W1983232753 hasConceptScore W1983232753C55493867 @default.
• W1983232753 hasConceptScore W1983232753C71315377 @default.
• W1983232753 hasConceptScore W1983232753C71924100 @default.
• W1983232753 hasConceptScore W1983232753C74864618 @default.
• W1983232753 hasConceptScore W1983232753C86803240 @default.
• W1983232753 hasConceptScore W1983232753C95444343 @default.
• W1983232753 hasIssue "6" @default.
• W1983232753 hasLocation W19832327531 @default.
• W1983232753 hasLocation W19832327532 @default.

• next