FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983243361> ?p ?o ?g. }

• W1983243361 endingPage "677" @default.
• W1983243361 startingPage "667" @default.
• W1983243361 abstract "Bexarotene is an RXR-selective vitamin A analog that has been shown to prevent ER-negative mammary tumorigenesis in animal models. While investigating the mechanism by which bexarotene prevents ER-negative breast cancer development, we found that the expression of cyclin D1, a critical cell cycle promoter, was repressed by bexarotene in vitro and in vivo. Time course and cycloheximide experiments show that repression of cyclin D1 is a late effect and requires new protein synthesis. Previously we discovered that DEC2 (differentially expressed in chondrocytes-2), a helix-loop-helix transcription repressor, was induced by bexarotene in human mammary epithelial cells. Therefore, we hypothesized that bexarotene represses the transcription of cyclin D1 through induction of DEC2. Luciferase reporter studies demonstrated that either bexarotene treatment or forced expression of DEC2 can repress the transcription of a cyclin D1 promoter reporter by affecting the basal transcriptional activity. Results from chromatin immunoprecipitation experiments showed that bexarotene treatment causes the recruitment of DEC2 and HDAC1 (histone deacetylase 1) to the cyclin D1 promoter. Co-immunoprecipitation confirms the interaction between DEC2 and HDAC1, suggesting that the recruitment of HDAC1 to the cyclin D1 promoter is through DEC2. Trichostatin A, a HDAC inhibitor, reverses the cyclin D1 repression by bexarotene, suggesting that repression of cyclin D1 involves histone deacetylation. Knock-down of DEC2 by siRNA abolishes the cyclin D1 repression, further supporting our hypothesis. Finally, we demonstrated that overexpression of DEC2 dramatically inhibited cell proliferation and repressed the expression of cyclin D1 in human mammary epithelial cells. These results suggest that bexarotene down-regulates cyclin D1 through induction of DEC2, followed by recruitment of HDAC1 to the cyclin D1 promoter causing transcriptional repression. By elucidating the mechanism by which rexinoids inhibit cell proliferation, it will be possible to develop more effective and less toxic drugs to prevent ER-negative breast cancers." @default.
• W1983243361 created "2016-06-24" @default.
• W1983243361 creator A5002803940 @default.
• W1983243361 creator A5018764359 @default.
• W1983243361 creator A5028189969 @default.
• W1983243361 creator A5064622016 @default.
• W1983243361 creator A5081212724 @default.
• W1983243361 creator A5085299879 @default.
• W1983243361 creator A5090053198 @default.
• W1983243361 date "2010-09-07" @default.
• W1983243361 modified "2023-09-25" @default.
• W1983243361 title "The rexinoid bexarotene represses cyclin D1 transcription by inducing the DEC2 transcriptional repressor" @default.
• W1983243361 cites W1989476306 @default.
• W1983243361 cites W1989768090 @default.
• W1983243361 cites W1992772703 @default.
• W1983243361 cites W2000012280 @default.
• W1983243361 cites W2003726111 @default.
• W1983243361 cites W2015794035 @default.
• W1983243361 cites W2021659183 @default.
• W1983243361 cites W2023553115 @default.
• W1983243361 cites W2041514890 @default.
• W1983243361 cites W2054196426 @default.
• W1983243361 cites W2065780150 @default.
• W1983243361 cites W2065951163 @default.
• W1983243361 cites W2077976952 @default.
• W1983243361 cites W2079829067 @default.
• W1983243361 cites W2083842309 @default.
• W1983243361 cites W2089306515 @default.
• W1983243361 cites W2090945807 @default.
• W1983243361 cites W2093188317 @default.
• W1983243361 cites W2106324853 @default.
• W1983243361 cites W2107859602 @default.
• W1983243361 cites W2117173730 @default.
• W1983243361 cites W2144670533 @default.
• W1983243361 cites W2146016818 @default.
• W1983243361 cites W2153863999 @default.
• W1983243361 cites W2156160936 @default.
• W1983243361 cites W2157573467 @default.
• W1983243361 cites W2181442264 @default.
• W1983243361 doi "https://doi.org/10.1007/s10549-010-1083-9" @default.
• W1983243361 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3444826" @default.
• W1983243361 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20821348" @default.
• W1983243361 hasPublicationYear "2010" @default.
• W1983243361 type Work @default.
• W1983243361 sameAs 1983243361 @default.
• W1983243361 citedByCount "33" @default.
• W1983243361 countsByYear W19832433612012 @default.
• W1983243361 countsByYear W19832433612013 @default.
• W1983243361 countsByYear W19832433612014 @default.
• W1983243361 countsByYear W19832433612015 @default.
• W1983243361 countsByYear W19832433612016 @default.
• W1983243361 countsByYear W19832433612017 @default.
• W1983243361 countsByYear W19832433612018 @default.
• W1983243361 countsByYear W19832433612019 @default.
• W1983243361 countsByYear W19832433612020 @default.
• W1983243361 countsByYear W19832433612021 @default.
• W1983243361 countsByYear W19832433612023 @default.
• W1983243361 crossrefType "journal-article" @default.
• W1983243361 hasAuthorship W1983243361A5002803940 @default.
• W1983243361 hasAuthorship W1983243361A5018764359 @default.
• W1983243361 hasAuthorship W1983243361A5028189969 @default.
• W1983243361 hasAuthorship W1983243361A5064622016 @default.
• W1983243361 hasAuthorship W1983243361A5081212724 @default.
• W1983243361 hasAuthorship W1983243361A5085299879 @default.
• W1983243361 hasAuthorship W1983243361A5090053198 @default.
• W1983243361 hasBestOaLocation W19832433612 @default.
• W1983243361 hasConcept C101762097 @default.
• W1983243361 hasConcept C104317684 @default.
• W1983243361 hasConcept C11882975 @default.
• W1983243361 hasConcept C134320426 @default.
• W1983243361 hasConcept C1491633281 @default.
• W1983243361 hasConcept C150194340 @default.
• W1983243361 hasConcept C153911025 @default.
• W1983243361 hasConcept C158448853 @default.
• W1983243361 hasConcept C16438837 @default.
• W1983243361 hasConcept C199835354 @default.
• W1983243361 hasConcept C2777865847 @default.
• W1983243361 hasConcept C2778305200 @default.
• W1983243361 hasConcept C2778820923 @default.
• W1983243361 hasConcept C28179978 @default.
• W1983243361 hasConcept C29537977 @default.
• W1983243361 hasConcept C502942594 @default.
• W1983243361 hasConcept C55493867 @default.
• W1983243361 hasConcept C63932345 @default.
• W1983243361 hasConcept C64927066 @default.
• W1983243361 hasConcept C86339819 @default.
• W1983243361 hasConcept C86803240 @default.
• W1983243361 hasConcept C9743823 @default.
• W1983243361 hasConceptScore W1983243361C101762097 @default.
• W1983243361 hasConceptScore W1983243361C104317684 @default.
• W1983243361 hasConceptScore W1983243361C11882975 @default.
• W1983243361 hasConceptScore W1983243361C134320426 @default.
• W1983243361 hasConceptScore W1983243361C1491633281 @default.
• W1983243361 hasConceptScore W1983243361C150194340 @default.
• W1983243361 hasConceptScore W1983243361C153911025 @default.
• W1983243361 hasConceptScore W1983243361C158448853 @default.
• W1983243361 hasConceptScore W1983243361C16438837 @default.
• W1983243361 hasConceptScore W1983243361C199835354 @default.

• next