Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983251354> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1983251354 endingPage "309" @default.
- W1983251354 startingPage "305" @default.
- W1983251354 abstract "Decreased circulating endothelial progenitor cells (EPCs) are considered as strong and robust biomarkers for the prediction of cardiovascular outcomes in diabetic populations. The perspectives for modulating EPCs levels in T2DM with known coronary artery disease (CAD) with different drugs, affected mechanisms of improving mobilization of EPCs from tissue, are not still understood. To evaluate an effect of angiotensin-2 receptor blocker valsartan on circulating level of EPCs in diabetic patients with asymptomatic CAD. The study population was structured retrospectively after determining the CAD by contrast-enhanced spiral computed tomography angiography in 126 asymptomatic subjects. All subjects were distributed into two cohorts depending on daily doses of valsartan given. Low (80–160 mg daily orally) and high doses (240–320 mg daily orally) of valsartan were used and they were adjusted depending on achieving BP level less than 140/80 mmHg. The change from baseline in CD34+ subset cells (frequencies and absolute values) was not significantly different between treatment cohorts. We found a significant increase of circulating level of CD14+CD309+ cells in two patient cohorts. But more prominent change of CD14+CD309+ cells was verified in subjects who were given valsartan in high daily doses when compared with persons who were included into cohort with low daily doses of the drug (1.96% versus 2.59%, respectively; P < 0.05). Therefore, both frequencies and absolute values in CD14+CD309+Tie2+ were increased significantly in patients who were treated with high doses of valsartan only. We found positive influence of angiotensin-2 receptor blocker valsartan in escalation doses on bone marrow-derived EPCs phenotyped as CD14+CD309+ and CD14+CD309+Tie2+ in T2DM patients with known asymptomatic CAD." @default.
- W1983251354 created "2016-06-24" @default.
- W1983251354 creator A5015250667 @default.
- W1983251354 creator A5038242220 @default.
- W1983251354 creator A5058148695 @default.
- W1983251354 creator A5064716604 @default.
- W1983251354 date "2015-10-01" @default.
- W1983251354 modified "2023-09-26" @default.
- W1983251354 title "The effect of angiotensin-2 receptor blocker valsartan on circulating level of endothelial progenitor cells in diabetic patients with asymptomatic coronary artery disease" @default.
- W1983251354 cites W1965499114 @default.
- W1983251354 cites W1969651995 @default.
- W1983251354 cites W1976291192 @default.
- W1983251354 cites W2003386912 @default.
- W1983251354 cites W2009555874 @default.
- W1983251354 cites W2042523497 @default.
- W1983251354 cites W2051808362 @default.
- W1983251354 cites W2080836044 @default.
- W1983251354 cites W2081103184 @default.
- W1983251354 cites W2081570709 @default.
- W1983251354 cites W2091118617 @default.
- W1983251354 cites W2101232009 @default.
- W1983251354 cites W2110049670 @default.
- W1983251354 cites W2116404316 @default.
- W1983251354 cites W2127872440 @default.
- W1983251354 cites W2142041241 @default.
- W1983251354 cites W2144145279 @default.
- W1983251354 cites W2153785016 @default.
- W1983251354 cites W2155965977 @default.
- W1983251354 cites W2990123797 @default.
- W1983251354 cites W4245379326 @default.
- W1983251354 doi "https://doi.org/10.1016/j.dsx.2014.04.006" @default.
- W1983251354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25470647" @default.
- W1983251354 hasPublicationYear "2015" @default.
- W1983251354 type Work @default.
- W1983251354 sameAs 1983251354 @default.
- W1983251354 citedByCount "5" @default.
- W1983251354 countsByYear W19832513542015 @default.
- W1983251354 countsByYear W19832513542017 @default.
- W1983251354 countsByYear W19832513542021 @default.
- W1983251354 countsByYear W19832513542022 @default.
- W1983251354 crossrefType "journal-article" @default.
- W1983251354 hasAuthorship W1983251354A5015250667 @default.
- W1983251354 hasAuthorship W1983251354A5038242220 @default.
- W1983251354 hasAuthorship W1983251354A5058148695 @default.
- W1983251354 hasAuthorship W1983251354A5064716604 @default.
- W1983251354 hasConcept C104849204 @default.
- W1983251354 hasConcept C126322002 @default.
- W1983251354 hasConcept C134018914 @default.
- W1983251354 hasConcept C164705383 @default.
- W1983251354 hasConcept C170493617 @default.
- W1983251354 hasConcept C201750760 @default.
- W1983251354 hasConcept C2777387769 @default.
- W1983251354 hasConcept C2777910003 @default.
- W1983251354 hasConcept C2778213512 @default.
- W1983251354 hasConcept C28328180 @default.
- W1983251354 hasConcept C2908929049 @default.
- W1983251354 hasConcept C54355233 @default.
- W1983251354 hasConcept C71924100 @default.
- W1983251354 hasConcept C84393581 @default.
- W1983251354 hasConcept C86803240 @default.
- W1983251354 hasConcept C90924648 @default.
- W1983251354 hasConceptScore W1983251354C104849204 @default.
- W1983251354 hasConceptScore W1983251354C126322002 @default.
- W1983251354 hasConceptScore W1983251354C134018914 @default.
- W1983251354 hasConceptScore W1983251354C164705383 @default.
- W1983251354 hasConceptScore W1983251354C170493617 @default.
- W1983251354 hasConceptScore W1983251354C201750760 @default.
- W1983251354 hasConceptScore W1983251354C2777387769 @default.
- W1983251354 hasConceptScore W1983251354C2777910003 @default.
- W1983251354 hasConceptScore W1983251354C2778213512 @default.
- W1983251354 hasConceptScore W1983251354C28328180 @default.
- W1983251354 hasConceptScore W1983251354C2908929049 @default.
- W1983251354 hasConceptScore W1983251354C54355233 @default.
- W1983251354 hasConceptScore W1983251354C71924100 @default.
- W1983251354 hasConceptScore W1983251354C84393581 @default.
- W1983251354 hasConceptScore W1983251354C86803240 @default.
- W1983251354 hasConceptScore W1983251354C90924648 @default.
- W1983251354 hasIssue "4" @default.
- W1983251354 hasLocation W19832513541 @default.
- W1983251354 hasLocation W19832513542 @default.
- W1983251354 hasOpenAccess W1983251354 @default.
- W1983251354 hasPrimaryLocation W19832513541 @default.
- W1983251354 hasRelatedWork W1966128948 @default.
- W1983251354 hasRelatedWork W1971613811 @default.
- W1983251354 hasRelatedWork W2027470168 @default.
- W1983251354 hasRelatedWork W2069855804 @default.
- W1983251354 hasRelatedWork W2111190158 @default.
- W1983251354 hasRelatedWork W2116962665 @default.
- W1983251354 hasRelatedWork W2132612653 @default.
- W1983251354 hasRelatedWork W2137237120 @default.
- W1983251354 hasRelatedWork W2172198736 @default.
- W1983251354 hasRelatedWork W1996764561 @default.
- W1983251354 hasVolume "9" @default.
- W1983251354 isParatext "false" @default.
- W1983251354 isRetracted "false" @default.
- W1983251354 magId "1983251354" @default.
- W1983251354 workType "article" @default.