FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983256073> ?p ?o ?g. }

• W1983256073 endingPage "1842" @default.
• W1983256073 startingPage "1839" @default.
• W1983256073 abstract "Tetracyclines, including tetracycline (TC), minocycline (MINO), and doxycycline (DOXY), were widely used as topical therapy in treating periodontitis, which is an infectious disease of the gingival crevice caused by periodontopathic bacteria. In addition, TC is used during bone grafting procedures because of its anticollagenase activity, antibacterial effect, and fibroblast-stimulatory properties.In this study, the effects of TC on osteoprecursor cells were evaluated. The cytotoxic effect was determined by testing cell viability. Differentiation and mineralization were evaluated using an alkaline phosphatase activity test and alizarin red S staining. In addition, protein expressions related to bone formation, such as bone morphogenetic protein 2 (BMP-2), estrogen receptor α (ER-α), and estrogen receptor β (ER-β), were evaluated by using Western blot analysis.The morphology of the cells seemed normal, and their viability was not significantly affected when they were treated with 10 μM MINO and 10 μM DOXY. Cells treated with 10 μM DOXY showed alkaline phosphatase activity that was comparable to the control. Results from the Western blot analysis showed that TC, MINO, and DOXY reduced the expression of BMP-2 and ER-β. Normalization of the protein expressions showed that 10 μM DOXY retained 87% in BMP-2 and 85% in ER-β.Higher levels of these agents led to a dose-dependent decrease of cellular differentiation and protein expression. There are several commercially available agents for TC, which has to be considered when applying the TC in local delivery applications." @default.
• W1983256073 created "2016-06-24" @default.
• W1983256073 creator A5054580241 @default.
• W1983256073 date "2011-09-01" @default.
• W1983256073 modified "2023-10-14" @default.
• W1983256073 title "Effects of Doxycycline, Minocycline, and Tetracycline on Cell Proliferation, Differentiation, and Protein Expression in Osteoprecursor Cells" @default.
• W1983256073 cites W1635459918 @default.
• W1983256073 cites W181114189 @default.
• W1983256073 cites W1864209824 @default.
• W1983256073 cites W1970621111 @default.
• W1983256073 cites W2004994936 @default.
• W1983256073 cites W2017838048 @default.
• W1983256073 cites W2063976278 @default.
• W1983256073 cites W2082673492 @default.
• W1983256073 cites W2083265178 @default.
• W1983256073 cites W2110714770 @default.
• W1983256073 cites W2169022241 @default.
• W1983256073 cites W4231535573 @default.
• W1983256073 doi "https://doi.org/10.1097/scs.0b013e31822e8216" @default.
• W1983256073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21959447" @default.
• W1983256073 hasPublicationYear "2011" @default.
• W1983256073 type Work @default.
• W1983256073 sameAs 1983256073 @default.
• W1983256073 citedByCount "41" @default.
• W1983256073 countsByYear W19832560732012 @default.
• W1983256073 countsByYear W19832560732013 @default.
• W1983256073 countsByYear W19832560732014 @default.
• W1983256073 countsByYear W19832560732015 @default.
• W1983256073 countsByYear W19832560732016 @default.
• W1983256073 countsByYear W19832560732017 @default.
• W1983256073 countsByYear W19832560732018 @default.
• W1983256073 countsByYear W19832560732019 @default.
• W1983256073 countsByYear W19832560732020 @default.
• W1983256073 countsByYear W19832560732021 @default.
• W1983256073 countsByYear W19832560732022 @default.
• W1983256073 countsByYear W19832560732023 @default.
• W1983256073 crossrefType "journal-article" @default.
• W1983256073 hasAuthorship W1983256073A5054580241 @default.
• W1983256073 hasConcept C104317684 @default.
• W1983256073 hasConcept C121608353 @default.
• W1983256073 hasConcept C126322002 @default.
• W1983256073 hasConcept C1491633281 @default.
• W1983256073 hasConcept C153911025 @default.
• W1983256073 hasConcept C160160445 @default.
• W1983256073 hasConcept C181199279 @default.
• W1983256073 hasConcept C202751555 @default.
• W1983256073 hasConcept C2776415932 @default.
• W1983256073 hasConcept C2777179404 @default.
• W1983256073 hasConcept C2778275353 @default.
• W1983256073 hasConcept C2780923616 @default.
• W1983256073 hasConcept C30352789 @default.
• W1983256073 hasConcept C501593827 @default.
• W1983256073 hasConcept C530470458 @default.
• W1983256073 hasConcept C53227056 @default.
• W1983256073 hasConcept C55493867 @default.
• W1983256073 hasConcept C71924100 @default.
• W1983256073 hasConcept C84606932 @default.
• W1983256073 hasConcept C86803240 @default.
• W1983256073 hasConcept C89423630 @default.
• W1983256073 hasConcept C98274493 @default.
• W1983256073 hasConceptScore W1983256073C104317684 @default.
• W1983256073 hasConceptScore W1983256073C121608353 @default.
• W1983256073 hasConceptScore W1983256073C126322002 @default.
• W1983256073 hasConceptScore W1983256073C1491633281 @default.
• W1983256073 hasConceptScore W1983256073C153911025 @default.
• W1983256073 hasConceptScore W1983256073C160160445 @default.
• W1983256073 hasConceptScore W1983256073C181199279 @default.
• W1983256073 hasConceptScore W1983256073C202751555 @default.
• W1983256073 hasConceptScore W1983256073C2776415932 @default.
• W1983256073 hasConceptScore W1983256073C2777179404 @default.
• W1983256073 hasConceptScore W1983256073C2778275353 @default.
• W1983256073 hasConceptScore W1983256073C2780923616 @default.
• W1983256073 hasConceptScore W1983256073C30352789 @default.
• W1983256073 hasConceptScore W1983256073C501593827 @default.
• W1983256073 hasConceptScore W1983256073C530470458 @default.
• W1983256073 hasConceptScore W1983256073C53227056 @default.
• W1983256073 hasConceptScore W1983256073C55493867 @default.
• W1983256073 hasConceptScore W1983256073C71924100 @default.
• W1983256073 hasConceptScore W1983256073C84606932 @default.
• W1983256073 hasConceptScore W1983256073C86803240 @default.
• W1983256073 hasConceptScore W1983256073C89423630 @default.
• W1983256073 hasConceptScore W1983256073C98274493 @default.
• W1983256073 hasIssue "5" @default.
• W1983256073 hasLocation W19832560731 @default.
• W1983256073 hasLocation W19832560732 @default.
• W1983256073 hasOpenAccess W1983256073 @default.
• W1983256073 hasPrimaryLocation W19832560731 @default.
• W1983256073 hasRelatedWork W1830184715 @default.
• W1983256073 hasRelatedWork W1985435370 @default.
• W1983256073 hasRelatedWork W1987882836 @default.
• W1983256073 hasRelatedWork W2007778924 @default.
• W1983256073 hasRelatedWork W2026623915 @default.
• W1983256073 hasRelatedWork W2029805742 @default.
• W1983256073 hasRelatedWork W2059063383 @default.
• W1983256073 hasRelatedWork W2128213617 @default.
• W1983256073 hasRelatedWork W2472109262 @default.
• W1983256073 hasRelatedWork W2186257442 @default.
• W1983256073 hasVolume "22" @default.

• next