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- W1983257041 abstract "In this article, we introduce a graphical approach to testing multiple hypotheses in group-sequential clinical trials allowing for midterm design modifications. It is intended for structured study objectives in adaptive clinical trials and extends the graphical group-sequential designs from Maurer and Bretz (Statistics in Biopharmaceutical Research 2013; 5: 311-320) to adaptive trial designs. The resulting test strategies can be visualized graphically and performed iteratively. We illustrate the methodology with two examples from our clinical trial practice. First, we consider a three-armed gold-standard trial with the option to reallocate patients to either the test drug or the active control group, while stopping the recruitment of patients to placebo, after having demonstrated superiority of the test drug over placebo at an interim analysis. Second, we consider a confirmatory two-stage adaptive design with treatment selection at interim." @default.
- W1983257041 created "2016-06-24" @default.
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- W1983257041 date "2014-11-05" @default.
- W1983257041 modified "2023-09-25" @default.
- W1983257041 title "A simple and flexible graphical approach for adaptive group-sequential clinical trials" @default.
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- W1983257041 doi "https://doi.org/10.1080/10543406.2014.972509" @default.
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