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• W1983257773 abstract "Purpose To assess the effect of changes in end-tidal partial pressure of O2 (PETO2) on cerebrovascular reactivity (CVR) estimated from changes in blood oxygen level–dependent (BOLD) signal during cyclic changes in end-tidal partial pressure of CO2 (PETCO2). Materials and Methods BOLD response to fixed cyclic step changes in PETCO2 (range = 30.4–48.8 mmHg) and PETO2 (range = 100.6–444.0 mmHg) was studied in four healthy volunteers. Results The BOLD reactivity to PETCO2 and PETO2 were 0.283 (0.188–0.379) (median, range) and 0.004 (0.003–0.006)%/mmHg, respectively, in the whole brain; 0.438 (0.382–0.614) vs. 0.006 (0.004–0.009)%/mmHg, respectively, in the gray matter; and 0.075 (0.065–0.093) vs. 0.002 (0.001–0.002)%/mmHg, respectively, in the white matter. Conclusion The BOLD reactivity to PETO2 was much smaller than that to PETCO2. However, BOLD reactivity can be significantly distorted by CO2-induced changes in PETO2. We conclude that PETO2 should be carefully controlled during studies that use BOLD reactivity as an indicator of CVR. J. Magn. Reson. Imaging 2007. © 2007 Wiley-Liss, Inc." @default.
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• W1983257773 date "2007-01-01" @default.
• W1983257773 modified "2023-09-27" @default.
• W1983257773 title "Comparison of the effects of independently-controlled end-tidal PCO2 and PO2 on blood oxygen level–dependent (BOLD) MRI" @default.
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• W1983257773 doi "https://doi.org/10.1002/jmri.21102" @default.
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