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• W1983257841 abstract "The amygdala has been proposed to serve as a neural center for the modulation of pain perception. Numerous anatomical and behavioral studies demonstrate that exogenous manipulations of the amygdala (i.e., lesions, drug infusions) modulate behavioral responses to acute noxious stimuli; however, little is known about the endogenous molecular changes in the amygdala that contribute to alterations in nociceptive processing during persistent noxious stimuli that resemble pathological pain conditions. In the present study, we demonstrate that endogenous molecular changes in the amygdala play a crucial role in modulating long-lasting peripheral hypersensitivity associated with persistent inflammation and we further identify the extracellular signal-regulated kinase (ERK) as a molecular substrate underlying this behavioral sensitization. Using the formalin test as a mouse model of persistent inflammatory pain, we show that activation of ERK in the amygdala is both necessary for and sufficient to induce long-lasting peripheral hypersensitivity to tactile stimulation. Thus, blockade of inflammation-induced ERK activation in the amygdala significantly reduced long-lasting peripheral hypersensitivity associated with persistent inflammation, and pharmacological activation of ERK in the amygdala induced peripheral hypersensitivity in the absence of inflammation. Importantly, blockade of ERK activation in the amygdala did not affect responses to acute noxious stimuli in the absence of inflammation, indicating that modulation of nociceptive responses by amygdala ERK activation is specific to the persistent inflammatory state. Altogether, our results demonstrate a functional role of the ERK signaling cascade in the amygdala in inflammation-induced peripheral hypersensitivity." @default.
• W1983257841 created "2016-06-24" @default.
• W1983257841 creator A5006363718 @default.
• W1983257841 creator A5057771387 @default.
• W1983257841 date "2007-02-14" @default.
• W1983257841 modified "2023-10-16" @default.
• W1983257841 title "Activation of the Extracellular Signal-Regulated Kinase in the Amygdala Modulates Pain Perception" @default.
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• W1983257841 doi "https://doi.org/10.1523/jneurosci.3536-06.2007" @default.
• W1983257841 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6673749" @default.
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