Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983267597> ?p ?o ?g. }
- W1983267597 endingPage "765" @default.
- W1983267597 startingPage "757" @default.
- W1983267597 abstract "T-type calcium channels are expressed in many diverse tissues, including neuronal, cardiovascular, and endocrine. T-type calcium channels are known to play roles in the development, maintenance, and repair of these tissues but have also been implicated in disease when not properly regulated. Calcium channel blockers have been developed to treat various diseases and their use clinically is widespread due to both their efficacy as well as their safety. Aside from their established clinical applications, recent studies have suggested neuroprotective effects of T-type calcium channel blockers. Many of the current T-type calcium channel blockers could act on other molecular targets besides T-type calcium channels making it uncertain whether their neuroprotective effects are solely due to blocking of T-type calcium channels. In this review, we discuss these drugs as well as newly developed chemical compounds that are designed to be more selective for T-type calcium channels. We review in vitro and in vivo evidence of neuroprotective effects by these T-type calcium channel blockers. We conclude by discussing possible molecular mechanisms underlying the neuroprotective effects by T-type calcium channel blockers." @default.
- W1983267597 created "2016-06-24" @default.
- W1983267597 creator A5010759884 @default.
- W1983267597 creator A5047210410 @default.
- W1983267597 creator A5078715944 @default.
- W1983267597 date "2014-02-25" @default.
- W1983267597 modified "2023-10-14" @default.
- W1983267597 title "T-type calcium channel blockers as neuroprotective agents" @default.
- W1983267597 cites W1540396301 @default.
- W1983267597 cites W1572617735 @default.
- W1983267597 cites W1797134060 @default.
- W1983267597 cites W1845779121 @default.
- W1983267597 cites W1964366976 @default.
- W1983267597 cites W1964501470 @default.
- W1983267597 cites W1969079932 @default.
- W1983267597 cites W1969945815 @default.
- W1983267597 cites W1972776272 @default.
- W1983267597 cites W1978279355 @default.
- W1983267597 cites W1984250589 @default.
- W1983267597 cites W1985234786 @default.
- W1983267597 cites W1986279601 @default.
- W1983267597 cites W1987332038 @default.
- W1983267597 cites W1989634849 @default.
- W1983267597 cites W1990721760 @default.
- W1983267597 cites W1990738189 @default.
- W1983267597 cites W1996862067 @default.
- W1983267597 cites W1996906033 @default.
- W1983267597 cites W1997544686 @default.
- W1983267597 cites W1997782840 @default.
- W1983267597 cites W1998854458 @default.
- W1983267597 cites W2002203475 @default.
- W1983267597 cites W2003107880 @default.
- W1983267597 cites W2007761930 @default.
- W1983267597 cites W2008608054 @default.
- W1983267597 cites W2008894450 @default.
- W1983267597 cites W2011310824 @default.
- W1983267597 cites W2011452596 @default.
- W1983267597 cites W2013889417 @default.
- W1983267597 cites W2014384074 @default.
- W1983267597 cites W2014787678 @default.
- W1983267597 cites W2016050384 @default.
- W1983267597 cites W2017236142 @default.
- W1983267597 cites W2028182180 @default.
- W1983267597 cites W2028474495 @default.
- W1983267597 cites W2032144918 @default.
- W1983267597 cites W2032683219 @default.
- W1983267597 cites W2034015985 @default.
- W1983267597 cites W2034266499 @default.
- W1983267597 cites W2034464833 @default.
- W1983267597 cites W2037248258 @default.
- W1983267597 cites W2037908792 @default.
- W1983267597 cites W2042036678 @default.
- W1983267597 cites W2046902346 @default.
- W1983267597 cites W2047894292 @default.
- W1983267597 cites W2052769676 @default.
- W1983267597 cites W2053260993 @default.
- W1983267597 cites W2063835667 @default.
- W1983267597 cites W2066288180 @default.
- W1983267597 cites W2071071180 @default.
- W1983267597 cites W2071734535 @default.
- W1983267597 cites W2073128951 @default.
- W1983267597 cites W2074692896 @default.
- W1983267597 cites W2076498796 @default.
- W1983267597 cites W2078205120 @default.
- W1983267597 cites W2079655984 @default.
- W1983267597 cites W2092604014 @default.
- W1983267597 cites W2096919198 @default.
- W1983267597 cites W2097607539 @default.
- W1983267597 cites W2114561675 @default.
- W1983267597 cites W2117370894 @default.
- W1983267597 cites W2125518902 @default.
- W1983267597 cites W2126901681 @default.
- W1983267597 cites W2130172845 @default.
- W1983267597 cites W2130862988 @default.
- W1983267597 cites W2131374239 @default.
- W1983267597 cites W2131759240 @default.
- W1983267597 cites W2136017767 @default.
- W1983267597 cites W2137549794 @default.
- W1983267597 cites W2141200794 @default.
- W1983267597 cites W2144238779 @default.
- W1983267597 cites W2145742025 @default.
- W1983267597 cites W2155711254 @default.
- W1983267597 cites W2157133007 @default.
- W1983267597 cites W2166860108 @default.
- W1983267597 cites W2187230393 @default.
- W1983267597 doi "https://doi.org/10.1007/s00424-014-1454-x" @default.
- W1983267597 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4005039" @default.
- W1983267597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24563219" @default.
- W1983267597 hasPublicationYear "2014" @default.
- W1983267597 type Work @default.
- W1983267597 sameAs 1983267597 @default.
- W1983267597 citedByCount "49" @default.
- W1983267597 countsByYear W19832675972014 @default.
- W1983267597 countsByYear W19832675972016 @default.
- W1983267597 countsByYear W19832675972017 @default.
- W1983267597 countsByYear W19832675972018 @default.
- W1983267597 countsByYear W19832675972019 @default.
- W1983267597 countsByYear W19832675972020 @default.