FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983269317> ?p ?o ?g. }

• W1983269317 endingPage "70" @default.
• W1983269317 startingPage "59" @default.
• W1983269317 abstract "Development and characterization of thermosensitive pluronic-based metronidazole in situ gelling formulations for vaginal application The purpose of this study was to develop pluronic-based in situ gelling formulations of metronidazole (MTZ) for treatment of bacterial vaginosis, aimed at prolonging the residence time, controlling drug release, enhancing efficacy, decreasing recurrence, and increasing patient compliance. The in situ gel formulations were prepared using different concentrations of pluronic F-127 (PF-127) alone and in combination with pluronic F-68 (PF-68). The prepared formulations were evaluated for their gelation temperature ( T gel ), in vitro drug release, rheological properties, mucoadhesion properties and tolerability by vaginal mucosa in tissue levels. The T gel decreased with increasing PF-127 concentration. The T gel was modulated by addition of PF-68 to be within the acceptable range of 25-37 °C. With increasing pluronic concentration, the in vitro drug release decreased, viscosity and mucoadhesive force increased. Histopathological examination of rabbit vaginas from the control and treated groups revealed normal histology of the vagina and cervix. Based on the in vitro evaluation of prepared formulations, the in situ gelling liquid formulated with PF-127/PF-68 (20/10 %, m/m ) was selected for further clinical evaluation." @default.
• W1983269317 created "2016-06-24" @default.
• W1983269317 creator A5025727972 @default.
• W1983269317 creator A5027832995 @default.
• W1983269317 creator A5043065075 @default.
• W1983269317 creator A5051274882 @default.
• W1983269317 creator A5066137701 @default.
• W1983269317 creator A5080002688 @default.
• W1983269317 date "2012-03-01" @default.
• W1983269317 modified "2023-10-16" @default.
• W1983269317 title "Development and characterization of thermosensitive pluronic-based metronidazole in situ gelling formulations for vaginal application" @default.
• W1983269317 cites W1965650360 @default.
• W1983269317 cites W1976236482 @default.
• W1983269317 cites W1994713846 @default.
• W1983269317 cites W1995488266 @default.
• W1983269317 cites W2009188082 @default.
• W1983269317 cites W2020965737 @default.
• W1983269317 cites W2030437443 @default.
• W1983269317 cites W2036700491 @default.
• W1983269317 cites W2037294386 @default.
• W1983269317 cites W2056255938 @default.
• W1983269317 cites W2056606423 @default.
• W1983269317 cites W2058509094 @default.
• W1983269317 cites W2072289465 @default.
• W1983269317 cites W2083306884 @default.
• W1983269317 cites W2099897485 @default.
• W1983269317 cites W2104717900 @default.
• W1983269317 cites W2144081123 @default.
• W1983269317 cites W2144280209 @default.
• W1983269317 cites W2156192330 @default.
• W1983269317 doi "https://doi.org/10.2478/v10007-012-0009-y" @default.
• W1983269317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22472449" @default.
• W1983269317 hasPublicationYear "2012" @default.
• W1983269317 type Work @default.
• W1983269317 sameAs 1983269317 @default.
• W1983269317 citedByCount "83" @default.
• W1983269317 countsByYear W19832693172013 @default.
• W1983269317 countsByYear W19832693172014 @default.
• W1983269317 countsByYear W19832693172015 @default.
• W1983269317 countsByYear W19832693172016 @default.
• W1983269317 countsByYear W19832693172017 @default.
• W1983269317 countsByYear W19832693172018 @default.
• W1983269317 countsByYear W19832693172019 @default.
• W1983269317 countsByYear W19832693172020 @default.
• W1983269317 countsByYear W19832693172021 @default.
• W1983269317 countsByYear W19832693172022 @default.
• W1983269317 countsByYear W19832693172023 @default.
• W1983269317 crossrefType "journal-article" @default.
• W1983269317 hasAuthorship W1983269317A5025727972 @default.
• W1983269317 hasAuthorship W1983269317A5027832995 @default.
• W1983269317 hasAuthorship W1983269317A5043065075 @default.
• W1983269317 hasAuthorship W1983269317A5051274882 @default.
• W1983269317 hasAuthorship W1983269317A5066137701 @default.
• W1983269317 hasAuthorship W1983269317A5080002688 @default.
• W1983269317 hasBestOaLocation W19832693171 @default.
• W1983269317 hasConcept C101335993 @default.
• W1983269317 hasConcept C13245373 @default.
• W1983269317 hasConcept C15920480 @default.
• W1983269317 hasConcept C178790620 @default.
• W1983269317 hasConcept C185592680 @default.
• W1983269317 hasConcept C2777396551 @default.
• W1983269317 hasConcept C2780020223 @default.
• W1983269317 hasConcept C2780035454 @default.
• W1983269317 hasConcept C2780306666 @default.
• W1983269317 hasConcept C43617362 @default.
• W1983269317 hasConcept C501593827 @default.
• W1983269317 hasConcept C521977710 @default.
• W1983269317 hasConcept C55493867 @default.
• W1983269317 hasConcept C71924100 @default.
• W1983269317 hasConcept C98274493 @default.
• W1983269317 hasConceptScore W1983269317C101335993 @default.
• W1983269317 hasConceptScore W1983269317C13245373 @default.
• W1983269317 hasConceptScore W1983269317C15920480 @default.
• W1983269317 hasConceptScore W1983269317C178790620 @default.
• W1983269317 hasConceptScore W1983269317C185592680 @default.
• W1983269317 hasConceptScore W1983269317C2777396551 @default.
• W1983269317 hasConceptScore W1983269317C2780020223 @default.
• W1983269317 hasConceptScore W1983269317C2780035454 @default.
• W1983269317 hasConceptScore W1983269317C2780306666 @default.
• W1983269317 hasConceptScore W1983269317C43617362 @default.
• W1983269317 hasConceptScore W1983269317C501593827 @default.
• W1983269317 hasConceptScore W1983269317C521977710 @default.
• W1983269317 hasConceptScore W1983269317C55493867 @default.
• W1983269317 hasConceptScore W1983269317C71924100 @default.
• W1983269317 hasConceptScore W1983269317C98274493 @default.
• W1983269317 hasIssue "1" @default.
• W1983269317 hasLocation W19832693171 @default.
• W1983269317 hasLocation W19832693172 @default.
• W1983269317 hasLocation W19832693173 @default.
• W1983269317 hasLocation W19832693174 @default.
• W1983269317 hasOpenAccess W1983269317 @default.
• W1983269317 hasPrimaryLocation W19832693171 @default.
• W1983269317 hasRelatedWork W1988819125 @default.
• W1983269317 hasRelatedWork W2046692960 @default.
• W1983269317 hasRelatedWork W2067517273 @default.
• W1983269317 hasRelatedWork W2077363171 @default.
• W1983269317 hasRelatedWork W2103043372 @default.
• W1983269317 hasRelatedWork W2383280096 @default.

• next