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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983270720> ?p ?o ?g. }

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• W1983270720 abstract "CYP11B1 inhibition is a promising therapy for Cushing’s syndrome. Starting from etomidate, references I and II, the title compounds were designed and synthesized. Cyclopropyl analogue 4 was identified as a CYP11B1 inhibitor more potent (IC50 = 2.2 nM) than leads and more selective (SF = 11) than I and metyrapone. Since it also showed potent inhibition of rat CYP11B1 and good selectivity over human CYP17 and CYP19, it is a promising candidate for further development." @default.
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• W1983270720 date "2012-07-12" @default.
• W1983270720 modified "2023-09-26" @default.
• W1983270720 title "Novel Imidazol-1-ylmethyl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-<i>ij</i>]quinolin-4-ones as Potent and Selective CYP11B1 Inhibitors for the Treatment of Cushing’s Syndrome" @default.
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• W1983270720 doi "https://doi.org/10.1021/jm3003872" @default.
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