Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983271726> ?p ?o ?g. }
- W1983271726 endingPage "e71" @default.
- W1983271726 startingPage "e61" @default.
- W1983271726 abstract "Background Multiple myeloma (MM) is characterized by accumulation of pathological plasma cells (PCs) in bone marrow (BM) as a result of deregulation of B-cell development. To clarify its pathophysiology it is necessary to investigate in detail the developmental stages of B-cells. Materials and Methods Enumeration of total CD19-positive (CD19+) cells and their subpopulations together with PCs was done in peripheral blood (PB) and BM of newly diagnosed monoclonal gammopathy patients and control subjects. Representation of subsets was compared among groups and relationships between subset percentage and cytogenetic/biochemical findings were analyzed. Results A lower number of total CD19+ cells was found in MM, particularly in advanced stages of disease. Reduction of naive (P < .01) and transitional B-cells (P < .05) and increase of switched memory and switched CD27− B-cells and germinal center founder cells were detected in PB of MM compared with controls (P < .01). Similar results were found in BM. β2 microglobulin level in MM positively correlated with the number of PCs and negatively with percentage of naive B-cells (P < .05). Conclusion Our results provided a detailed phenotypic profile and enumeration of B and PC subpopulations in monoclonal gammopathy patients. A reduced number of B-cells and particularly a differentiation shift to more numerous antigen-stimulated forms was observed in MM. This might indicate a potential source of myeloma-initiating cells in one of these subpopulations." @default.
- W1983271726 created "2016-06-24" @default.
- W1983271726 creator A5012247336 @default.
- W1983271726 creator A5020329152 @default.
- W1983271726 creator A5021420657 @default.
- W1983271726 creator A5024814555 @default.
- W1983271726 creator A5031121132 @default.
- W1983271726 creator A5039402772 @default.
- W1983271726 creator A5048828638 @default.
- W1983271726 creator A5050249175 @default.
- W1983271726 creator A5058464853 @default.
- W1983271726 creator A5090512266 @default.
- W1983271726 creator A5091155004 @default.
- W1983271726 date "2015-04-01" @default.
- W1983271726 modified "2023-10-17" @default.
- W1983271726 title "Analysis of B-Cell Subpopulations in Monoclonal Gammopathies" @default.
- W1983271726 cites W1625913856 @default.
- W1983271726 cites W1963761129 @default.
- W1983271726 cites W1970371303 @default.
- W1983271726 cites W1979640049 @default.
- W1983271726 cites W1982836586 @default.
- W1983271726 cites W1989829520 @default.
- W1983271726 cites W1990826881 @default.
- W1983271726 cites W1991287193 @default.
- W1983271726 cites W2030750674 @default.
- W1983271726 cites W2038783844 @default.
- W1983271726 cites W2056013867 @default.
- W1983271726 cites W2056703680 @default.
- W1983271726 cites W2067615548 @default.
- W1983271726 cites W2067885146 @default.
- W1983271726 cites W2086703018 @default.
- W1983271726 cites W2087468792 @default.
- W1983271726 cites W2095162291 @default.
- W1983271726 cites W2099868898 @default.
- W1983271726 cites W2100761378 @default.
- W1983271726 cites W2116909043 @default.
- W1983271726 cites W2121411022 @default.
- W1983271726 cites W2122874647 @default.
- W1983271726 cites W2123510004 @default.
- W1983271726 cites W2126260163 @default.
- W1983271726 cites W2129806278 @default.
- W1983271726 cites W2133951067 @default.
- W1983271726 cites W2138582495 @default.
- W1983271726 cites W2140568894 @default.
- W1983271726 cites W2146819767 @default.
- W1983271726 cites W2156049613 @default.
- W1983271726 cites W2156221438 @default.
- W1983271726 cites W2160617791 @default.
- W1983271726 cites W226917763 @default.
- W1983271726 cites W2312208711 @default.
- W1983271726 cites W4238040389 @default.
- W1983271726 doi "https://doi.org/10.1016/j.clml.2014.12.003" @default.
- W1983271726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25578543" @default.
- W1983271726 hasPublicationYear "2015" @default.
- W1983271726 type Work @default.
- W1983271726 sameAs 1983271726 @default.
- W1983271726 citedByCount "5" @default.
- W1983271726 countsByYear W19832717262016 @default.
- W1983271726 countsByYear W19832717262020 @default.
- W1983271726 countsByYear W19832717262022 @default.
- W1983271726 crossrefType "journal-article" @default.
- W1983271726 hasAuthorship W1983271726A5012247336 @default.
- W1983271726 hasAuthorship W1983271726A5020329152 @default.
- W1983271726 hasAuthorship W1983271726A5021420657 @default.
- W1983271726 hasAuthorship W1983271726A5024814555 @default.
- W1983271726 hasAuthorship W1983271726A5031121132 @default.
- W1983271726 hasAuthorship W1983271726A5039402772 @default.
- W1983271726 hasAuthorship W1983271726A5048828638 @default.
- W1983271726 hasAuthorship W1983271726A5050249175 @default.
- W1983271726 hasAuthorship W1983271726A5058464853 @default.
- W1983271726 hasAuthorship W1983271726A5090512266 @default.
- W1983271726 hasAuthorship W1983271726A5091155004 @default.
- W1983271726 hasConcept C147483822 @default.
- W1983271726 hasConcept C153911025 @default.
- W1983271726 hasConcept C159654299 @default.
- W1983271726 hasConcept C163864487 @default.
- W1983271726 hasConcept C203014093 @default.
- W1983271726 hasConcept C2776364478 @default.
- W1983271726 hasConcept C2776396001 @default.
- W1983271726 hasConcept C2778453870 @default.
- W1983271726 hasConcept C2778957590 @default.
- W1983271726 hasConcept C2780007613 @default.
- W1983271726 hasConcept C542903549 @default.
- W1983271726 hasConcept C86803240 @default.
- W1983271726 hasConcept C96926380 @default.
- W1983271726 hasConceptScore W1983271726C147483822 @default.
- W1983271726 hasConceptScore W1983271726C153911025 @default.
- W1983271726 hasConceptScore W1983271726C159654299 @default.
- W1983271726 hasConceptScore W1983271726C163864487 @default.
- W1983271726 hasConceptScore W1983271726C203014093 @default.
- W1983271726 hasConceptScore W1983271726C2776364478 @default.
- W1983271726 hasConceptScore W1983271726C2776396001 @default.
- W1983271726 hasConceptScore W1983271726C2778453870 @default.
- W1983271726 hasConceptScore W1983271726C2778957590 @default.
- W1983271726 hasConceptScore W1983271726C2780007613 @default.
- W1983271726 hasConceptScore W1983271726C542903549 @default.
- W1983271726 hasConceptScore W1983271726C86803240 @default.
- W1983271726 hasConceptScore W1983271726C96926380 @default.