FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983275479> ?p ?o ?g. }

• W1983275479 endingPage "18" @default.
• W1983275479 startingPage "13" @default.
• W1983275479 abstract "Background Recurrent pregnancy loss (RPL) has been associated with impaired maternal–fetal communication. Protease-activated-receptor 1 (PAR1) is critical for trophoblast invasion and establishment unrelated to its role in vascular biology. Objectives To analyze whether polymorphisms of PAR1 [-1426C/T], [-506I/D], and/or IVS[-14A/T] are associated with unexplained RPL. Patients/methods A case-control pilot study conducted in 39 healthy women with history of unexplained RPL and 98 women with a full-term, uncomplicated deliveries and no history of RPL. Results Women with RPL were significantly more likely to be heterozygous for [-1426C/T] (12.8% versus 3.2%; p = 0.049); the heterozygous state for IVS[-14A/T] was also more common (15.4% versus 4.4%; p = 0.064). There was no difference between groups for [-506I/D] genotypes. The functional consequence for [-1426C/T] and IVS[-14A/T] polymorphisms is underscored by the markedly low PAR1 mRNA levels in those women. Bioinformatics indicate generation of a new consensus motif for repressor Kruppel-like factor 3 (KLF3) in [-1426T]. Moreover, chromatin immunoprecipitation (ChIP) analysis confirmed a physical association between KLF3 protein and the hPar1 DNA obtained from women with the [-1426C/T] polymorphism. Conclusions We hypothesize that the significantly low PAR1 levels impact placenta establishment and consequently pregnancy outcome, thereby profiling a novel risk factor for unexplained RPL." @default.
• W1983275479 created "2016-06-24" @default.
• W1983275479 creator A5007695089 @default.
• W1983275479 creator A5009196860 @default.
• W1983275479 creator A5009493674 @default.
• W1983275479 creator A5035887794 @default.
• W1983275479 creator A5037017678 @default.
• W1983275479 creator A5038039997 @default.
• W1983275479 creator A5065253165 @default.
• W1983275479 creator A5080721505 @default.
• W1983275479 date "2015-02-01" @default.
• W1983275479 modified "2023-09-24" @default.
• W1983275479 title "Protease-activated-receptor 1 polymorphisms correlate with risk for unexplained recurrent pregnancy loss: a pilot study querying an association beyond coagulation" @default.
• W1983275479 cites W1811402656 @default.
• W1983275479 cites W1975868622 @default.
• W1983275479 cites W1976841572 @default.
• W1983275479 cites W1985078311 @default.
• W1983275479 cites W1985119800 @default.
• W1983275479 cites W1992165616 @default.
• W1983275479 cites W2006049280 @default.
• W1983275479 cites W2010286870 @default.
• W1983275479 cites W2037458235 @default.
• W1983275479 cites W2039068650 @default.
• W1983275479 cites W2039156905 @default.
• W1983275479 cites W2040250767 @default.
• W1983275479 cites W2042082129 @default.
• W1983275479 cites W2046801755 @default.
• W1983275479 cites W2047655212 @default.
• W1983275479 cites W2058711758 @default.
• W1983275479 cites W2066540510 @default.
• W1983275479 cites W2089509408 @default.
• W1983275479 cites W2090204011 @default.
• W1983275479 cites W2110755408 @default.
• W1983275479 cites W2115559832 @default.
• W1983275479 cites W2115960869 @default.
• W1983275479 cites W2116665656 @default.
• W1983275479 cites W2118094114 @default.
• W1983275479 cites W2139882703 @default.
• W1983275479 cites W2148470385 @default.
• W1983275479 cites W2152646926 @default.
• W1983275479 cites W2153787746 @default.
• W1983275479 cites W2156690021 @default.
• W1983275479 cites W2164486137 @default.
• W1983275479 cites W2319251802 @default.
• W1983275479 cites W2322561651 @default.
• W1983275479 cites W2475201971 @default.
• W1983275479 cites W2104283275 @default.
• W1983275479 doi "https://doi.org/10.1016/j.ejogrb.2014.11.021" @default.
• W1983275479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25496845" @default.
• W1983275479 hasPublicationYear "2015" @default.
• W1983275479 type Work @default.
• W1983275479 sameAs 1983275479 @default.
• W1983275479 citedByCount "4" @default.
• W1983275479 countsByYear W19832754792016 @default.
• W1983275479 countsByYear W19832754792017 @default.
• W1983275479 countsByYear W19832754792018 @default.
• W1983275479 countsByYear W19832754792020 @default.
• W1983275479 crossrefType "journal-article" @default.
• W1983275479 hasAuthorship W1983275479A5007695089 @default.
• W1983275479 hasAuthorship W1983275479A5009196860 @default.
• W1983275479 hasAuthorship W1983275479A5009493674 @default.
• W1983275479 hasAuthorship W1983275479A5035887794 @default.
• W1983275479 hasAuthorship W1983275479A5037017678 @default.
• W1983275479 hasAuthorship W1983275479A5038039997 @default.
• W1983275479 hasAuthorship W1983275479A5065253165 @default.
• W1983275479 hasAuthorship W1983275479A5080721505 @default.
• W1983275479 hasConcept C101762097 @default.
• W1983275479 hasConcept C104317684 @default.
• W1983275479 hasConcept C126322002 @default.
• W1983275479 hasConcept C134320426 @default.
• W1983275479 hasConcept C135763542 @default.
• W1983275479 hasConcept C146304588 @default.
• W1983275479 hasConcept C150194340 @default.
• W1983275479 hasConcept C172680121 @default.
• W1983275479 hasConcept C203014093 @default.
• W1983275479 hasConcept C2776953305 @default.
• W1983275479 hasConcept C2777495146 @default.
• W1983275479 hasConcept C2779234561 @default.
• W1983275479 hasConcept C54355233 @default.
• W1983275479 hasConcept C71924100 @default.
• W1983275479 hasConcept C86803240 @default.
• W1983275479 hasConceptScore W1983275479C101762097 @default.
• W1983275479 hasConceptScore W1983275479C104317684 @default.
• W1983275479 hasConceptScore W1983275479C126322002 @default.
• W1983275479 hasConceptScore W1983275479C134320426 @default.
• W1983275479 hasConceptScore W1983275479C135763542 @default.
• W1983275479 hasConceptScore W1983275479C146304588 @default.
• W1983275479 hasConceptScore W1983275479C150194340 @default.
• W1983275479 hasConceptScore W1983275479C172680121 @default.
• W1983275479 hasConceptScore W1983275479C203014093 @default.
• W1983275479 hasConceptScore W1983275479C2776953305 @default.
• W1983275479 hasConceptScore W1983275479C2777495146 @default.
• W1983275479 hasConceptScore W1983275479C2779234561 @default.
• W1983275479 hasConceptScore W1983275479C54355233 @default.
• W1983275479 hasConceptScore W1983275479C71924100 @default.
• W1983275479 hasConceptScore W1983275479C86803240 @default.
• W1983275479 hasLocation W19832754791 @default.
• W1983275479 hasLocation W19832754792 @default.

• next