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- W1983275558 abstract "The synthesis, radiochemical analysis and biological characteristics of some 1,8-diamine-3,6-dithiaoctane derivatives labelled with Tc-99m are reported. Analysis by HPLC shows that most of the 99mTc-chelates are multicomponent. Furthermore, almost all 99mTc-complexes isolated by HPLC are lipophilic and stable in vitro. The biodistributions of the most lipophilic of these complexes were evaluated in mice. The N-morpholinylethyl and N,N'-bisalicylyl derivatives of 1,8-diamine-3,6-dithiaoctane yielded 99mTc-complexes which exhibit considerable uptake and retention in organs of interest, such as the heart and the brain." @default.
- W1983275558 created "2016-06-24" @default.
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- W1983275558 date "1992-05-01" @default.
- W1983275558 modified "2023-09-30" @default.
- W1983275558 title "Synthesis, radiochemistry and biological evaluation of technetium-99m complexes with 1,8-diamine-3,6-dithiaoctane (DDO) ligands" @default.
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- W1983275558 doi "https://doi.org/10.1016/0883-2897(92)90162-r" @default.
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