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• W1983283512 abstract "Four hundred and sixty-one adult subjects with migraine were randomised to one of five treatments, the oral antagonist at the calcitonin gene-related peptide (CGRP) receptor BI 44370 TA (50 mg, 200 mg, 400 mg), active comparator eletriptan 40 mg or placebo. The analysis included 341 subjects who took study medication.The primary endpoint, pain-free after two hours, was reached by significantly more subjects in the BI 44370 TA 400 mg (20/73 = 27.4%) and eletriptan 40 mg (24/69 = 34.8%) groups compared to placebo (6/70 = 8.6%, p = .0016), but not by subjects in the BI 44370 TA 200 mg group (14/65 = 21.5%). The effect of 50 mg BI 44370 TA (5/64 = 7.8%) was similar to that of placebo. Analysis of secondary endpoints supported the conclusion from the primary analysis. The frequency of adverse events was low in all groups.Efficacy of BI 44370 TA was shown in a dose-dependent manner in the treatment of acute migraine attacks." @default.
• W1983283512 created "2016-06-24" @default.
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• W1983283512 date "2010-12-20" @default.
• W1983283512 modified "2023-10-01" @default.
• W1983283512 title "BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: Results from a phase II study" @default.
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• W1983283512 doi "https://doi.org/10.1177/0333102410388435" @default.
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