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- W1983284219 abstract "Increases in cytosolic Ca2+ concentration ([Ca2+]i) mediated by NMDA-sensitive glutamate receptors (NMDARs) are important for synaptic plasticity. We studied a wide variety of dendritic spines on rat CA1 pyramidal neurons in acute hippocampal slices. Two-photon uncaging and Ca2+ imaging revealed that NMDAR-mediated currents increased with spine-head volume and that even the smallest spines contained a significant number of NMDARs. The fate of Ca2+ that entered spine heads through NMDARs was governed by the shape (length and radius) of the spine neck. Larger spines had necks that permitted greater efflux of Ca2+ into the dendritic shaft, whereas smaller spines manifested a larger increase in [Ca2+]i within the spine compartment as a result of a smaller Ca2+ flux through the neck. Spine-neck geometry is thus an important determinant of spine Ca2+ signaling, allowing small spines to be the preferential sites for isolated induction of long-term potentiation." @default.
- W1983284219 created "2016-06-24" @default.
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- W1983284219 date "2005-05-01" @default.
- W1983284219 modified "2023-10-13" @default.
- W1983284219 title "Spine-Neck Geometry Determines NMDA Receptor-Dependent Ca2+ Signaling in Dendrites" @default.
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- W1983284219 doi "https://doi.org/10.1016/j.neuron.2005.03.015" @default.
- W1983284219 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4151245" @default.
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