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- W1983284328 abstract "In our effort directed toward the discovery of new anti-diabetic agent for the treatment of diabetes, a library of biscoumarin derivative 1–18 was synthesized and evaluated for α-glucosidase inhibitory potential. All eighteen (18) compounds displayed assorted α-glucosidase activity with IC50 values 16.5–385.9 μM, if compared with the standard acarbose (IC50 = 906 ± 6.387 μM). In addition, molecular docking studies were carried out to explore the binding interactions of biscoumarin derivatives with the enzyme. This study has identified a new class of potent α-glucosidase inhibitors." @default.
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- W1983284328 date "2014-06-01" @default.
- W1983284328 modified "2023-10-14" @default.
- W1983284328 title "Synthesis and molecular docking studies of potent α-glucosidase inhibitors based on biscoumarin skeleton" @default.
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- W1983284328 doi "https://doi.org/10.1016/j.ejmech.2014.05.010" @default.
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