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- W1983290017 abstract "Dr. Lewis and Dr. Schulman (November 24, p. 1159) discussed their demonstration that gestation is prolonged in patients with arthritis taking aspirin in terms of prostaglandin metabolism at the end of pregnancy. On the other hand, perhaps the delay came much earlier, during the periimplantation period. For example, when rats were fed a saturated solution of sodium salicylate acid, the development of the decidual cell reaction was much reduced on day 7 of pregnancy (day 0 was the day of sperm in the vagina). This experiment was performed because the decidual cell reaction to the invading blastocyst seemed to resemble the physiology of acute inflammation elsewhere in the body, as evidenced by the suppression of the increased capillary permeability to Evans-blue characteristic of the early hours of nidation by sodium salicylate. It may be that arthritics on aspirin have a decreased rate of deciduoma growth in the early weeks of gestation, as did the rat." @default.
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- W1983290017 date "1974-01-01" @default.
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- W1983290017 title "ASPIRIN, PROSTAGLANDIN, AND GESTATION" @default.
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- W1983290017 doi "https://doi.org/10.1016/s0140-6736(74)93029-3" @default.
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