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- W1983291219 abstract "A novel synthetic model biomembrane consisting of a polymeric matrix containing several natural membrane constituents has been developed that exhibits permeation characteristics often attributed to natural biological membranes. When used to separate two aqueous phases buffered at physiological pH's, the model membrane constitutes an experimental system simulating gastrointestinal absorption. The transport of salicylic acid from a chamber at pH 2.0 (A) through the synthetic membrane and into a receiving chamber at pH 7.4 (C) follows apparent first-order kinetics. Support is given to a proposed kinetic model of A → C because of negligible membrane retention and minimal back-transport of the test drug. The rate of disappearance from A approximated the rate of appearance in C. The model system more closely simulates in vivo conditions than previously used three-phase liquid in vitro models. The pH-partition hypothesis is examined using this experimental system, the results indicating that the unionized, lipidsoluble species is the only form of the drug to permeate the synthetic biomembrane readily." @default.
- W1983291219 created "2016-06-24" @default.
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- W1983291219 date "1971-03-01" @default.
- W1983291219 modified "2023-09-27" @default.
- W1983291219 title "Drug Permeation through Thin Model Membranes II: Permeation Characteristics of a Polymeric Model Biomembrane" @default.
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- W1983291219 doi "https://doi.org/10.1002/jps.2600600311" @default.
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