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- W1983296676 abstract "Isolated preparations of the rat submandibular gland secreted when perfused at a rate of 3 ml/min with physiological salt solutions containing glucose and either acetylcholine (10−9 to 10−4 M) or pilocarpine (10−7 to 10−3 M). The maximum secretory response was 250 μl g−1 min−1 with acetylcholine (10−6 M) and 130 μl g−1 min−1 with pilocarpine (10−6 M). Higher agonist concentrations usually resulted in smaller secretory responses. The response to continued stimulation showed a slow decline, although it was more sustained than with a similar preparation of the rabbit submandibular gland. The excretion curves for Na, K, Ca, Cl and HCO3 evoked by the two parasympatho-mimetic agonists were similar to those reported from in-vivo experiments. Ouabain (10−3 M), the substitution of Na by Li or the omission of K in the perfusion solution markedly inhibited the secretory response from the isolated, perfused-gland preparation. Partial substitution of the perfusate Na with choline caused only partial inhibition of secretion, but decreased Na and increased Ca and K concentrations in saliva. It is concluded that the perfused-gland preparation functions normally with respect to the secretion of fluid and electrolytes, and offers a suitable vehicle for investigation of the salivary secretory process. The sublingual gland secreted in response to pilocarpine. The maximum secretory rate was 130 μl g−1 min−1 and the saliva was poor in Na and Cl and rich in K, HCO3 and Ca." @default.
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- W1983296676 title "Fluid and electrolyte secretion from the isolated, perfused submandibular and sublingual glands of the rat" @default.
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- W1983296676 doi "https://doi.org/10.1016/0003-9969(81)90017-0" @default.
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