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- W1983297411 abstract "CD40--which is expressed on endothelial cells and antigen-presenting cells, such as B cells, macrophages and dendritic cells--is a glycoprotein receptor for T cell-expressed CD40-ligand. CD40 signaling leads to production of both pro-inflammatory and anti-inflammatory mediators. Some of these mediators, such as vascular endothelial growth factor, help in angiogenesis, forming new capillaries. Although these capillaries can function as conduits for tumor-cell metastasis, these same vessels can also be a gateway for entry of activated anti-tumor effector cells that eliminate tumors. How such countercurrent processes can be turned in favor of anti-tumor immunity remains to be shown." @default.
- W1983297411 created "2016-06-24" @default.
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- W1983297411 date "2007-11-01" @default.
- W1983297411 modified "2023-10-12" @default.
- W1983297411 title "CD40-induced countercurrent conduits for tumor escape or elimination?" @default.
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- W1983297411 doi "https://doi.org/10.1016/j.it.2007.08.010" @default.
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