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- W1983297903 abstract "[reaction: see text] Oligonucleotides with novel modifications, 2'-O-[2-(methoxy)ethyl]-2-thiothymidine and 2'-deoxy-2'-fluoro-2-thiothymidine, have been synthesized. These modified oligonucleotides exhibited very high thermal stability when hybridized with complementary RNA. 2-O-(2-Methoxy)ethyl-2-thiothymidine modified oligonucleotide phosphodiesters showed enhanced resistance toward nucleases (t(1/2) > 24 h), but 2'-deoxy-2'-fluoro-2-thiothymidine modified oligonucleotide phosphodiesters showed limited stability to nucleotytic degradation." @default.
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- W1983297903 date "2003-08-01" @default.
- W1983297903 modified "2023-09-26" @default.
- W1983297903 title "2‘-Modified-2-thiothymidine Oligonucleotides" @default.
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- W1983297903 doi "https://doi.org/10.1021/ol0348607" @default.
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