Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983313117> ?p ?o ?g. }
- W1983313117 endingPage "466" @default.
- W1983313117 startingPage "452" @default.
- W1983313117 abstract "Store-operated Ca(2+) entry (SOCE) is an important Ca(2+) influx pathway in non-excitable cells. STIM1, an ER Ca(2+) sensor, and Orai1, a plasma membrane Ca(2+) selective channel, are the two essential components of the Ca(2+) release activated channel (CRAC) responsible for SOCE activity. Here we explored the role of STIM1 and Orai1 in neural differentiation of mouse embryonic stem (ES) cells. We found that STIM1 and Orai1 were expressed and functionally active in ES cells, and expressions of STIM1 and Orai1 were dynamically regulated during neural differentiation of mouse ES cells. STIM1 knockdown inhibited the differentiation of mouse ES cells into neural progenitors, neurons, and astrocytes. In addition, STIM1 knockdown caused severe cell death and markedly suppressed the proliferation of neural progenitors. Surprisingly, Orai1 knockdown had little effect on neural differentiation of mouse ES cells, but the neurons derived from Orai1 knockdown ES cells, like those from STIM1 knockdown cells, had defective SOCE. Taken together, our data indicate that STIM1 is involved in both early neural differentiation of ES cells and survival of early differentiated ES cells independent of Orai1-mediated SOCE." @default.
- W1983313117 created "2016-06-24" @default.
- W1983313117 creator A5022560446 @default.
- W1983313117 creator A5026066382 @default.
- W1983313117 creator A5046225712 @default.
- W1983313117 creator A5070999565 @default.
- W1983313117 creator A5081372942 @default.
- W1983313117 creator A5084817298 @default.
- W1983313117 date "2014-03-01" @default.
- W1983313117 modified "2023-10-18" @default.
- W1983313117 title "Role of STIM1 in survival and neural differentiation of mouse embryonic stem cells independent of Orai1-mediated Ca2+ entry" @default.
- W1983313117 cites W1485297825 @default.
- W1983313117 cites W1597582492 @default.
- W1983313117 cites W1652680663 @default.
- W1983313117 cites W1966476278 @default.
- W1983313117 cites W1972826154 @default.
- W1983313117 cites W1974361256 @default.
- W1983313117 cites W1975703347 @default.
- W1983313117 cites W1979573280 @default.
- W1983313117 cites W1981088384 @default.
- W1983313117 cites W1982861164 @default.
- W1983313117 cites W1989920563 @default.
- W1983313117 cites W1991686320 @default.
- W1983313117 cites W1997788514 @default.
- W1983313117 cites W2001726213 @default.
- W1983313117 cites W2001917660 @default.
- W1983313117 cites W2007639643 @default.
- W1983313117 cites W2009991455 @default.
- W1983313117 cites W2012278053 @default.
- W1983313117 cites W2020033048 @default.
- W1983313117 cites W2021494076 @default.
- W1983313117 cites W2031958964 @default.
- W1983313117 cites W2038127512 @default.
- W1983313117 cites W2042342392 @default.
- W1983313117 cites W2044409707 @default.
- W1983313117 cites W2045899482 @default.
- W1983313117 cites W2053135501 @default.
- W1983313117 cites W2058521801 @default.
- W1983313117 cites W2062118486 @default.
- W1983313117 cites W2067949982 @default.
- W1983313117 cites W2069112909 @default.
- W1983313117 cites W2069989784 @default.
- W1983313117 cites W2077591858 @default.
- W1983313117 cites W2077685412 @default.
- W1983313117 cites W2080897541 @default.
- W1983313117 cites W2092319653 @default.
- W1983313117 cites W2095104495 @default.
- W1983313117 cites W2098142640 @default.
- W1983313117 cites W2098240553 @default.
- W1983313117 cites W2098465830 @default.
- W1983313117 cites W2104441302 @default.
- W1983313117 cites W2104793567 @default.
- W1983313117 cites W2105342942 @default.
- W1983313117 cites W2109101169 @default.
- W1983313117 cites W2110015307 @default.
- W1983313117 cites W2112645751 @default.
- W1983313117 cites W2125151502 @default.
- W1983313117 cites W2127493263 @default.
- W1983313117 cites W2130128490 @default.
- W1983313117 cites W2131284696 @default.
- W1983313117 cites W2137249515 @default.
- W1983313117 cites W2137258759 @default.
- W1983313117 cites W2140336088 @default.
- W1983313117 cites W2140480753 @default.
- W1983313117 cites W2144258854 @default.
- W1983313117 cites W2146341872 @default.
- W1983313117 cites W2150163104 @default.
- W1983313117 cites W2155621930 @default.
- W1983313117 cites W2158331725 @default.
- W1983313117 cites W2158561340 @default.
- W1983313117 cites W2161210718 @default.
- W1983313117 cites W2163789582 @default.
- W1983313117 cites W2165671896 @default.
- W1983313117 cites W4247741685 @default.
- W1983313117 cites W4255760236 @default.
- W1983313117 doi "https://doi.org/10.1016/j.scr.2013.12.005" @default.
- W1983313117 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24424349" @default.
- W1983313117 hasPublicationYear "2014" @default.
- W1983313117 type Work @default.
- W1983313117 sameAs 1983313117 @default.
- W1983313117 citedByCount "23" @default.
- W1983313117 countsByYear W19833131172014 @default.
- W1983313117 countsByYear W19833131172015 @default.
- W1983313117 countsByYear W19833131172016 @default.
- W1983313117 countsByYear W19833131172017 @default.
- W1983313117 countsByYear W19833131172018 @default.
- W1983313117 countsByYear W19833131172019 @default.
- W1983313117 countsByYear W19833131172020 @default.
- W1983313117 countsByYear W19833131172021 @default.
- W1983313117 countsByYear W19833131172022 @default.
- W1983313117 countsByYear W19833131172023 @default.
- W1983313117 crossrefType "journal-article" @default.
- W1983313117 hasAuthorship W1983313117A5022560446 @default.
- W1983313117 hasAuthorship W1983313117A5026066382 @default.
- W1983313117 hasAuthorship W1983313117A5046225712 @default.
- W1983313117 hasAuthorship W1983313117A5070999565 @default.
- W1983313117 hasAuthorship W1983313117A5081372942 @default.
- W1983313117 hasAuthorship W1983313117A5084817298 @default.