Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983316106> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1983316106 abstract "Mature and old B6AF1 and B6D2F1 mice were given acidified tap water or promethazine HCl (a phenothiazine with H1 receptor blocking activity), chlorpheniramine (an H1 blocker) or trifluoperazine (a phenothiazine with no H1 blocking activity) in their drinking water, and the effects of these agents on bone mineral content were assessed by intermittently measuring the 24-h whole body retention of Tc 99m methylene diphosphonate (Tc 99m MDP, an indicator of bone metabolism) and at the end of the studies by determining ash weights of femur, ilium and sacrum. It was found that 24-h retention of Tc 99m MDP was elevated in old mice as it is in old osteopenic humans, that promethazine but not chlorpheniramine or trifluoperazine inhibited bone loss in aging mice, and that there was a correlation between decrease in retention of Tc 99m MDP and decreased bone loss. These preliminary results suggest that the ability of promethazine to inhibit age-related bone loss may not be mediated through its action as an H1 blocker or as a phenothiazine. However, more agents of each type need to be tested before this point can be established." @default.
- W1983316106 created "2016-06-24" @default.
- W1983316106 creator A5067668040 @default.
- W1983316106 creator A5069049599 @default.
- W1983316106 date "1986-08-01" @default.
- W1983316106 modified "2023-09-25" @default.
- W1983316106 title "Age-related osteopenia in the mouse: Effects of an H1 blocker, a phenothiazine, and promethazine" @default.
- W1983316106 cites W1480687248 @default.
- W1983316106 cites W1561385509 @default.
- W1983316106 cites W1964799645 @default.
- W1983316106 cites W1966258864 @default.
- W1983316106 cites W1970742097 @default.
- W1983316106 cites W1972304950 @default.
- W1983316106 cites W1985442688 @default.
- W1983316106 cites W2004652312 @default.
- W1983316106 cites W2012600477 @default.
- W1983316106 cites W2015849427 @default.
- W1983316106 cites W2022874584 @default.
- W1983316106 cites W2032379197 @default.
- W1983316106 cites W2076263545 @default.
- W1983316106 cites W2088326112 @default.
- W1983316106 cites W2103280894 @default.
- W1983316106 cites W2114122932 @default.
- W1983316106 cites W2125517704 @default.
- W1983316106 cites W2164915964 @default.
- W1983316106 cites W2319788194 @default.
- W1983316106 cites W2324462150 @default.
- W1983316106 cites W2324669770 @default.
- W1983316106 cites W2331112163 @default.
- W1983316106 cites W2423275130 @default.
- W1983316106 cites W2430034147 @default.
- W1983316106 doi "https://doi.org/10.1016/0047-6374(86)90129-6" @default.
- W1983316106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2877124" @default.
- W1983316106 hasPublicationYear "1986" @default.
- W1983316106 type Work @default.
- W1983316106 sameAs 1983316106 @default.
- W1983316106 citedByCount "5" @default.
- W1983316106 crossrefType "journal-article" @default.
- W1983316106 hasAuthorship W1983316106A5067668040 @default.
- W1983316106 hasAuthorship W1983316106A5069049599 @default.
- W1983316106 hasConcept C126322002 @default.
- W1983316106 hasConcept C134018914 @default.
- W1983316106 hasConcept C181199279 @default.
- W1983316106 hasConcept C185592680 @default.
- W1983316106 hasConcept C2775891158 @default.
- W1983316106 hasConcept C2778716775 @default.
- W1983316106 hasConcept C2778794651 @default.
- W1983316106 hasConcept C29688787 @default.
- W1983316106 hasConcept C55493867 @default.
- W1983316106 hasConcept C71924100 @default.
- W1983316106 hasConcept C98274493 @default.
- W1983316106 hasConceptScore W1983316106C126322002 @default.
- W1983316106 hasConceptScore W1983316106C134018914 @default.
- W1983316106 hasConceptScore W1983316106C181199279 @default.
- W1983316106 hasConceptScore W1983316106C185592680 @default.
- W1983316106 hasConceptScore W1983316106C2775891158 @default.
- W1983316106 hasConceptScore W1983316106C2778716775 @default.
- W1983316106 hasConceptScore W1983316106C2778794651 @default.
- W1983316106 hasConceptScore W1983316106C29688787 @default.
- W1983316106 hasConceptScore W1983316106C55493867 @default.
- W1983316106 hasConceptScore W1983316106C71924100 @default.
- W1983316106 hasConceptScore W1983316106C98274493 @default.
- W1983316106 hasLocation W19833161061 @default.
- W1983316106 hasLocation W19833161062 @default.
- W1983316106 hasOpenAccess W1983316106 @default.
- W1983316106 hasPrimaryLocation W19833161061 @default.
- W1983316106 hasRelatedWork W1983316106 @default.
- W1983316106 hasRelatedWork W1987060263 @default.
- W1983316106 hasRelatedWork W2045313643 @default.
- W1983316106 hasRelatedWork W2128860739 @default.
- W1983316106 hasRelatedWork W2168019880 @default.
- W1983316106 hasRelatedWork W2315017822 @default.
- W1983316106 hasRelatedWork W2424125530 @default.
- W1983316106 hasRelatedWork W1985515781 @default.
- W1983316106 hasRelatedWork W2284107246 @default.
- W1983316106 hasRelatedWork W3111716164 @default.
- W1983316106 isParatext "false" @default.
- W1983316106 isRetracted "false" @default.
- W1983316106 magId "1983316106" @default.
- W1983316106 workType "article" @default.