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- W1983325679 abstract "Sculptra (Dermik Laboratories, A Division of Aventis Pharmaceuticals, Inc., Berwyn, PA) was approved by the US Food and Drug Administration (FDA) on August 3, 2004 as the first synthetic injectable medical device for the treatment of HIV-related facial lipoatrophy [ [1] Klein R, Struble K. US Food and Drug Admisinstration. FDA approval of Sculptra for treating HIV facial lipoatrophy. Available at: www.fda.gov//bbs/topics/news/2004/NEW0100.html. Accessed 5/6/06. Google Scholar ]. HIV lipodystrophy syndrome is a complication of highly active antiretroviral therapy (HAART) with protease inhibitors (PIs) or nucleoside reverse transcriptase inhibitors (NRTIs) [ 2 Kravcik S. HIV lipodystrophy: a review. HIV Clin Trials. 2000; 1: 37-50 Crossref PubMed Scopus (14) Google Scholar , 3 Mallon P.W.G. Cooper D.A. Carr A. HIV-associated lipodystrophy. HIV Med. 2001; 2: 166-173 Crossref PubMed Scopus (48) Google Scholar , 4 John M. Nolan D. Mallal S. Antiretroviral therapy and the lipodystrophy syndrome. Antivir Ther. 2001; 6 ([Review]): 9-20 PubMed Google Scholar , 5 Nolan D. John M. Mallal S. Antiretroviral therapy and the lipodystrophy syndrome, part 2: concepts in aetiopathogenesis. Antivir Ther. 2001; 6 ([Review]): 145-160 PubMed Google Scholar , 6 Garcia-Viejo M.A. Ruiz M. Martinez E. Strategies for treating HIV-related lipodystrophy. Expert Opin invest Drugs. 2001; 10: 1443-1456 Crossref PubMed Scopus (19) Google Scholar , 7 Qaqish R.B. Fisher E. Rublein J. et al. HIV lipodystrophy syndrome. Pharmacotherapy. 2000; 20: 13-22 Crossref PubMed Scopus (47) Google Scholar ]. HIV lipodystrophy syndrome is characterized by metabolic abnormalities, central fat hypertrophy, and peripheral fat atrophy. Metabolic aberrations (insulin resistance/diabetes, hypercholesterolemia, and hypertriglyceridemia) and central fat hypertrophy are more commonly seen with PIs, whereas NRTIs are more likely to contribute to fat wasting or lipoatrophy [ [6] Garcia-Viejo M.A. Ruiz M. Martinez E. Strategies for treating HIV-related lipodystrophy. Expert Opin invest Drugs. 2001; 10: 1443-1456 Crossref PubMed Scopus (19) Google Scholar ]. Metabolic changes may eventually require medication with oral hypoglycemic, antilipid agents, or both." @default.
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- W1983325679 date "2006-10-01" @default.
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- W1983325679 title "Sculptra: the New Three-Dimensional Filler" @default.
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- W1983325679 doi "https://doi.org/10.1016/j.cps.2006.09.001" @default.
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