FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983327325> ?p ?o ?g. }

• W1983327325 endingPage "1200" @default.
• W1983327325 startingPage "1192" @default.
• W1983327325 abstract "The induction of LH receptors by exogenous and endogenous cAMP was examined in granulosa cells from ovaries of hypophysectomized diethylstilbestrol-implanted rats. During the 96-h culture period, FSH stimulated cAMP production, protein synthesis, progesterone formation, and the expression of LH receptors. cAMP accumulation and LH receptor formation were stimulated by 2.5–10 ng FSH, and were maximal at 72 h of culture with 175 ng FSH. Progesterone production peaked after 48 h of culture, but required 25 ng FSH to initiate steroidogenesis and 375 ng for the maximal response. In cells cultured with 5 mM 8-bromo-cAMP (8-Br-cAMP), progesterone production at 48 h was similar to that stimulated by FSH, and LH receptor formation was one third as much as with FSH. Removal of 8-BrcAMP after 48 h of culture caused a fall in LH receptors and progesterone production at 96 h, indicating that continual presence of the cyclic nucleotide was required for the maintenance of granulosa cell function. The LH receptors induced by FSH and 8-Br-cAMP were functionally active, since LH raised progesterone production 15-fold in FSH-treated cells and 3-fold after 8-Br-cAMP treatment. The phosphodiesterase inhibitor 1-methyl-3-isobutylxanthine elevated FSH-stimulated cAMP and progesterone accumulation, but inhibited LH receptor formation and the incorporation of [3H]leucine into granulosa cell protein in a concentration-dependent manner. Simultaneous addition of 8-Br-cAMP or choleragen with increasing concentrations of FSH indicated that enhancement of cAMP accumulation or cAMPdependent pathways synergistically increased LH receptor formation and progesterone production. Incubation of granulosa cells with both FSH and choleragen also resulted in supraadditive accumulation of cAMP. These results indicate that cAMP is required for both the induction and maintenance of LH receptors and steroidogenic enzymes during differentiation of the ovarian granulosa cell." @default.
• W1983327325 created "2016-06-24" @default.
• W1983327325 creator A5007314582 @default.
• W1983327325 creator A5085269523 @default.
• W1983327325 date "1982-10-01" @default.
• W1983327325 modified "2023-10-14" @default.
• W1983327325 title "Induction of Luteinizing Hormone Receptors by Adenosine 3',5'-Monophosphate in Cultured Granulosa Cells" @default.
• W1983327325 cites W1481096871 @default.
• W1983327325 cites W1488242159 @default.
• W1983327325 cites W1550914515 @default.
• W1983327325 cites W1971932969 @default.
• W1983327325 cites W1977516555 @default.
• W1983327325 cites W1978198363 @default.
• W1983327325 cites W1981216250 @default.
• W1983327325 cites W1985394131 @default.
• W1983327325 cites W1996238789 @default.
• W1983327325 cites W2002667424 @default.
• W1983327325 cites W2002934776 @default.
• W1983327325 cites W2008535216 @default.
• W1983327325 cites W2014410972 @default.
• W1983327325 cites W2014863394 @default.
• W1983327325 cites W2015354988 @default.
• W1983327325 cites W2017440399 @default.
• W1983327325 cites W2021445249 @default.
• W1983327325 cites W2021504472 @default.
• W1983327325 cites W2041675777 @default.
• W1983327325 cites W2043178059 @default.
• W1983327325 cites W2048000482 @default.
• W1983327325 cites W2049599205 @default.
• W1983327325 cites W2061782885 @default.
• W1983327325 cites W2064982147 @default.
• W1983327325 cites W2067728820 @default.
• W1983327325 cites W2077754316 @default.
• W1983327325 cites W2083158575 @default.
• W1983327325 cites W2089262455 @default.
• W1983327325 cites W2097979364 @default.
• W1983327325 cites W2107529467 @default.
• W1983327325 cites W2122136523 @default.
• W1983327325 cites W2124218309 @default.
• W1983327325 cites W2199857208 @default.
• W1983327325 cites W2334708595 @default.
• W1983327325 cites W2409029961 @default.
• W1983327325 cites W2413061961 @default.
• W1983327325 cites W2419396513 @default.
• W1983327325 cites W2422137763 @default.
• W1983327325 doi "https://doi.org/10.1210/endo-111-4-1192" @default.
• W1983327325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6180889" @default.
• W1983327325 hasPublicationYear "1982" @default.
• W1983327325 type Work @default.
• W1983327325 sameAs 1983327325 @default.
• W1983327325 citedByCount "71" @default.
• W1983327325 countsByYear W19833273252014 @default.
• W1983327325 countsByYear W19833273252015 @default.
• W1983327325 crossrefType "journal-article" @default.
• W1983327325 hasAuthorship W1983327325A5007314582 @default.
• W1983327325 hasAuthorship W1983327325A5085269523 @default.
• W1983327325 hasConcept C126322002 @default.
• W1983327325 hasConcept C134018914 @default.
• W1983327325 hasConcept C170493617 @default.
• W1983327325 hasConcept C181199279 @default.
• W1983327325 hasConcept C185592680 @default.
• W1983327325 hasConcept C2777203538 @default.
• W1983327325 hasConcept C2778575703 @default.
• W1983327325 hasConcept C2778782382 @default.
• W1983327325 hasConcept C2779279165 @default.
• W1983327325 hasConcept C29390026 @default.
• W1983327325 hasConcept C55493867 @default.
• W1983327325 hasConcept C62826618 @default.
• W1983327325 hasConcept C71315377 @default.
• W1983327325 hasConcept C71924100 @default.
• W1983327325 hasConcept C86803240 @default.
• W1983327325 hasConceptScore W1983327325C126322002 @default.
• W1983327325 hasConceptScore W1983327325C134018914 @default.
• W1983327325 hasConceptScore W1983327325C170493617 @default.
• W1983327325 hasConceptScore W1983327325C181199279 @default.
• W1983327325 hasConceptScore W1983327325C185592680 @default.
• W1983327325 hasConceptScore W1983327325C2777203538 @default.
• W1983327325 hasConceptScore W1983327325C2778575703 @default.
• W1983327325 hasConceptScore W1983327325C2778782382 @default.
• W1983327325 hasConceptScore W1983327325C2779279165 @default.
• W1983327325 hasConceptScore W1983327325C29390026 @default.
• W1983327325 hasConceptScore W1983327325C55493867 @default.
• W1983327325 hasConceptScore W1983327325C62826618 @default.
• W1983327325 hasConceptScore W1983327325C71315377 @default.
• W1983327325 hasConceptScore W1983327325C71924100 @default.
• W1983327325 hasConceptScore W1983327325C86803240 @default.
• W1983327325 hasIssue "4" @default.
• W1983327325 hasLocation W19833273251 @default.
• W1983327325 hasLocation W19833273252 @default.
• W1983327325 hasOpenAccess W1983327325 @default.
• W1983327325 hasPrimaryLocation W19833273251 @default.
• W1983327325 hasRelatedWork W1981222718 @default.
• W1983327325 hasRelatedWork W1988349415 @default.
• W1983327325 hasRelatedWork W1988926993 @default.
• W1983327325 hasRelatedWork W2067589401 @default.
• W1983327325 hasRelatedWork W2085434721 @default.
• W1983327325 hasRelatedWork W2086384643 @default.
• W1983327325 hasRelatedWork W2101899607 @default.

• next