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- W1983340279 abstract "We have examined some effects of 2ndash;diethylaminoethyl- 2,2-diphenylvalerate HC1 (SKF 525-A), an inhibitor of hepatic drug metabolism and of cytochrome P-450-mediated reactions, on T4 metabolism by rat liver slices and by rats in vivo. Incubation of liver slices with labeled T4 in medium containing 0.1 mM SKF 525-A reduced deiodination to 27% of control and did not affect T3 formation; at 1.0 mM SKF 525-A, deiodination and T3 formation both declined (to 7% and 60% of control levels, respectively), while degradation of rT3 was not affected. Hypoxia had effects similar to SKF 525-A, i.e. inhibition of T4 deiodination, while formation of T3 from T4 and degradation of rT3 were not inhibited. During a constant infusion of [125I]T4, SKF 525-A (3.5 mg/100 g BW, ip) caused an acute increase in the MCR of T4. It was then found that SKF 525-A added to serum in vitro increased the free T4 fraction; injected in vivo, it caused a prompt rise in the free T4 fraction accompanied by a fall in serum TSH. In rats receiv..." @default.
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- W1983340279 date "1981-04-01" @default.
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- W1983340279 title "Effects of an Inhibitor of Hepatic Drug Metabolism, 2 Diethylaminoethyl-2,2-Diphenylvalerate HC1 (SKF 525-A), on Thyroxine Metabolism in the Rat" @default.
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- W1983340279 doi "https://doi.org/10.1210/endo-108-4-1519" @default.
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