FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W198339934> ?p ?o ?g. }

• W198339934 abstract "To explore epigenetic regulation and the impact of chemokine CXCL14 on colorectal cancer, 7 colorectal cancer cell lines, 107 cases of primary colorectal cancer, and 10 cases of normal colorectal mucosa were evaluated in this study. Methylation specific PCR (MSP), semi-quantitative reverse-transcription PCR (RT-PCR), cell proliferation assay, colony formation, and transwell assay were performed for the evaluation. Complete methylation and loss of CXCL14 expression were found in 5 colorectal cancer cell lines. Partial methylation and weak expression were found in two cell lines. CXCL14 was methylated in 79.4% (85/107) of primary human colorectal cancer. No methylation was found in 10 cases of normal colorectal mucosa. Restoration of CXCL14 expression was induced by the 5-aza-2'-deoxycytidine (DAC) treatment. The cell viability was reduced and colony formation was inhibited by restoration of CXCL14 expression in HCT116 cells, a colorectal cancer cell line. The number of invasive and migration cells was reduced by CXCL14. The expression of MMP-2, Vimentin, and NF-κB was suppressed, and the expression of E-cadherin and IκB-α was induced by CXCL14. In conclusion, CXCL14 is frequently methylated in human colorectal cancer and promoter region hypermethylation silenced CXCL14 expression in colorectal cancer cells. Restoration of CXCL14 expression suppressed colorectal cancer proliferation. CXCL14 inhibits colorectal cancer migration, invasion, and epithelial-to-mesenchymal transition (EMT) by suppressing NF-κB signaling." @default.
• W198339934 created "2016-06-24" @default.
• W198339934 creator A5012377120 @default.
• W198339934 creator A5015545603 @default.
• W198339934 creator A5017114335 @default.
• W198339934 creator A5038831545 @default.
• W198339934 creator A5040081599 @default.
• W198339934 creator A5078965698 @default.
• W198339934 creator A5083607904 @default.
• W198339934 date "2013-10-01" @default.
• W198339934 modified "2023-09-22" @default.
• W198339934 title "Epigenetic silencing of CXCL14 induced colorectal cancer migration and invasion." @default.
• W198339934 cites W1572090578 @default.
• W198339934 cites W1620262541 @default.
• W198339934 cites W1649213427 @default.
• W198339934 cites W1966403084 @default.
• W198339934 cites W1967009979 @default.
• W198339934 cites W1967811733 @default.
• W198339934 cites W1990017150 @default.
• W198339934 cites W2006961090 @default.
• W198339934 cites W2019889666 @default.
• W198339934 cites W2030384822 @default.
• W198339934 cites W2037092974 @default.
• W198339934 cites W2038536875 @default.
• W198339934 cites W2042276775 @default.
• W198339934 cites W2043267841 @default.
• W198339934 cites W2048359072 @default.
• W198339934 cites W2055727614 @default.
• W198339934 cites W2061018632 @default.
• W198339934 cites W2061623083 @default.
• W198339934 cites W2073166594 @default.
• W198339934 cites W2075293884 @default.
• W198339934 cites W2083931304 @default.
• W198339934 cites W2089300758 @default.
• W198339934 cites W2102615088 @default.
• W198339934 cites W2106787323 @default.
• W198339934 cites W2125093701 @default.
• W198339934 cites W2133406201 @default.
• W198339934 cites W2135421977 @default.
• W198339934 cites W2141290206 @default.
• W198339934 cites W2153999077 @default.
• W198339934 cites W3024803511 @default.
• W198339934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4061567" @default.
• W198339934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24099668" @default.
• W198339934 hasPublicationYear "2013" @default.
• W198339934 type Work @default.
• W198339934 sameAs 198339934 @default.
• W198339934 citedByCount "25" @default.
• W198339934 countsByYear W1983399342015 @default.
• W198339934 countsByYear W1983399342016 @default.
• W198339934 countsByYear W1983399342017 @default.
• W198339934 countsByYear W1983399342018 @default.
• W198339934 countsByYear W1983399342019 @default.
• W198339934 countsByYear W1983399342020 @default.
• W198339934 countsByYear W1983399342021 @default.
• W198339934 countsByYear W1983399342022 @default.
• W198339934 countsByYear W1983399342023 @default.
• W198339934 crossrefType "journal-article" @default.
• W198339934 hasAuthorship W198339934A5012377120 @default.
• W198339934 hasAuthorship W198339934A5015545603 @default.
• W198339934 hasAuthorship W198339934A5017114335 @default.
• W198339934 hasAuthorship W198339934A5038831545 @default.
• W198339934 hasAuthorship W198339934A5040081599 @default.
• W198339934 hasAuthorship W198339934A5078965698 @default.
• W198339934 hasAuthorship W198339934A5083607904 @default.
• W198339934 hasConcept C104317684 @default.
• W198339934 hasConcept C111669997 @default.
• W198339934 hasConcept C119056186 @default.
• W198339934 hasConcept C121608353 @default.
• W198339934 hasConcept C12823836 @default.
• W198339934 hasConcept C13373296 @default.
• W198339934 hasConcept C150194340 @default.
• W198339934 hasConcept C153911025 @default.
• W198339934 hasConcept C190727270 @default.
• W198339934 hasConcept C203014093 @default.
• W198339934 hasConcept C2776914184 @default.
• W198339934 hasConcept C33288867 @default.
• W198339934 hasConcept C41091548 @default.
• W198339934 hasConcept C45240729 @default.
• W198339934 hasConcept C502942594 @default.
• W198339934 hasConcept C526805850 @default.
• W198339934 hasConcept C54355233 @default.
• W198339934 hasConcept C86803240 @default.
• W198339934 hasConceptScore W198339934C104317684 @default.
• W198339934 hasConceptScore W198339934C111669997 @default.
• W198339934 hasConceptScore W198339934C119056186 @default.
• W198339934 hasConceptScore W198339934C121608353 @default.
• W198339934 hasConceptScore W198339934C12823836 @default.
• W198339934 hasConceptScore W198339934C13373296 @default.
• W198339934 hasConceptScore W198339934C150194340 @default.
• W198339934 hasConceptScore W198339934C153911025 @default.
• W198339934 hasConceptScore W198339934C190727270 @default.
• W198339934 hasConceptScore W198339934C203014093 @default.
• W198339934 hasConceptScore W198339934C2776914184 @default.
• W198339934 hasConceptScore W198339934C33288867 @default.
• W198339934 hasConceptScore W198339934C41091548 @default.
• W198339934 hasConceptScore W198339934C45240729 @default.
• W198339934 hasConceptScore W198339934C502942594 @default.
• W198339934 hasConceptScore W198339934C526805850 @default.
• W198339934 hasConceptScore W198339934C54355233 @default.

• next