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- W1983399384 abstract "Summary Lymphocyte proliferation and cytokine production were measured in groups of mice vaccinated (but not subsequently challenge infected) with recombinant forms of Schistosoma japonicum cathepsin D aspartic protease, rSjASP1 (expressed in bacteria; enzymatically inactive) and rSjASP2 (expressed in insect cells; enzymatically active). Both forms of the schistosome enzyme induced significant proliferation of splenocytes recovered from vaccinated mice, and expression of interferon (IFN)‐γ, interleukin (IL)‐4 and IL‐10 mRNA in these cells was detected using reverse transcriptase‐polymerase chain reaction. Secretion of IFN‐γ, IL‐4 and IL‐10 by splenocytes from vaccinated mice was confirmed and quantified using enzyme‐linked immunosorbent assay. IFN‐γ was the most abundant cytokine produced, followed by IL‐4 and IL‐10 in rank order. These findings indicated that vaccination of mice with the schistosome protease induces a mixed Th1/Th2 cytokine response, which may explain the modest level of protection after challenge infection in cathepsin d ‐vaccinated mice, reported previously." @default.
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- W1983399384 date "2002-07-01" @default.
- W1983399384 modified "2023-10-18" @default.
- W1983399384 title "Cellular responses to Schistosoma japonicum cathepsin D aspartic protease" @default.
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- W1983399384 doi "https://doi.org/10.1046/j.1365-3024.2002.00475.x" @default.
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