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• W1983403560 abstract "Abstract Background The primary objective of this study was to determine the efficiency of a pneumatic device in controlling cuff pressure (P cuff ) in patients intubated with polyurethane-cuffed tracheal tubes. Secondary objectives were to determine the impact of continuous control of P cuff , and cuff shape on microaspiration of gastric contents. Methods Prospective randomized controlled study. All patients requiring intubation and mechanical ventilation ≥48 h were eligible. The first 32 patients were intubated with tapered polyurethane-cuffed, and the 32 following patients were intubated with cylindrical polyurethane-cuffed tracheal tubes. Patients randomly received 24 h of continuous control of P cuff using a pneumatic device (Nosten®), and 24 h of routine care of P cuff using a manometer. Target P cuff was 25 cmH 2 O. P cuff was continuously recorded, and pepsin was quantitatively measured in all tracheal aspirates during these periods. Results The pneumatic device was efficient in controlling P cuff (med [IQ] 26 [24, 28] vs 22 [20, 28] cmH 2 O, during continuous control of P cuff and routine care, respectively; p = 0.017). In addition, percentage of patients with underinflation (31% vs 68%) or overinflation (53% vs 100%) of tracheal cuff, and percentage of time spent with underinflation (0.9 [0, 17] vs 14% [4, 30]) or overinflation (0 [0, 2] vs 32% [9, 54]) were significantly (p < 0.001) reduced during continuous control of P cuff compared with routine care. No significant difference was found in microaspiration of gastric content between continuous control of P cuff compared with routine care, or between patients intubated with tapered compared with cylindrical polyurethane-cuffed tracheal tubes. Conclusion The pneumatic device was efficient in controlling P cuff in critically ill patients intubated with polyurethane-cuffed tracheal tubes. Trial registration The Australian New Zealand Clinical Trials Registry ( NCT01351259 )" @default.
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• W1983403560 date "2013-12-01" @default.
• W1983403560 modified "2023-10-09" @default.
• W1983403560 title "Efficiency of a pneumatic device in controlling cuff pressure of polyurethane-cuffed tracheal tubes: a randomized controlled study" @default.
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• W1983403560 doi "https://doi.org/10.1186/1471-2253-13-50" @default.
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