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- W1983409097 abstract "Xenobiotics such as phenobarbital, 2,3,7,8-tetrachlorodibenzo-p-dioxin, and Aroclor 1254 significantly suppress the activity of a key gluconeogenic and glyceroneogenic enzyme, phosphoenolpyruvate carboxykinase (PEPCK), suggesting that xenobiotics disrupt hepatic glucose and fat metabolism. The effects of polybrominated diphenyl ethers (PBDE), a family of synthetic flame-retardant chemicals, on PEPCK activity is unknown. This study investigated the effect of DE-71, a commercial PBDE mixture, on PEPCK enzyme kinetics. Forty-eight 1-mo-old male Wistar rats were gavaged daily with either corn oil or corn oil containing 14 mg/kg DE-71 for 3, 14, or 28 d (n = 8/group). At each time point, fasting plasma glucose, insulin, and C-peptide were measured and hepatic PEPCK activity, lipid content, and three cytochrome P-450 enzymes (CYP1A, -2B, and -3A) were assayed. PBDE treatment for 28 d significantly decreased PEPCK Vmax (μmol/min/g liver weight) by 43% and increased liver lipid by 20%, compared to control. CYP1A, -2B, and -3A Vmax values were enhanced by 5-, 6-, and 39-fold, respectively, at both 14 and 28 d in treated rats compared to control. There was a significant inverse and temporal correlation between CYP3A and PEPCK Vmax for the treatment group. Fasting plasma glucose, insulin, and C-peptide levels were not markedly affected by treatment, but the glucose:insulin ratio was significantly higher in treated compared to control rats. Data suggest that in vivo PBDE treatment compromises liver glucose and lipid metabolism, and may influence whole-body insulin sensitivity." @default.
- W1983409097 created "2016-06-24" @default.
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- W1983409097 date "2013-01-01" @default.
- W1983409097 modified "2023-10-08" @default.
- W1983409097 title "Polybrominated Diphenyl Ethers Alter Hepatic Phosphoenolpyruvate Carboxykinase Enzyme Kinetics in Male Wistar Rats: Implications for Lipid and Glucose Metabolism" @default.
- W1983409097 cites W1507096872 @default.
- W1983409097 cites W1585693958 @default.
- W1983409097 cites W1915827411 @default.
- W1983409097 cites W191850656 @default.
- W1983409097 cites W1919215073 @default.
- W1983409097 cites W1964334073 @default.
- W1983409097 cites W1967062147 @default.
- W1983409097 cites W1968084836 @default.
- W1983409097 cites W1970915874 @default.
- W1983409097 cites W1974551762 @default.
- W1983409097 cites W1975288925 @default.
- W1983409097 cites W1984490307 @default.
- W1983409097 cites W1987012880 @default.
- W1983409097 cites W1987227107 @default.
- W1983409097 cites W1989314811 @default.
- W1983409097 cites W1992092887 @default.
- W1983409097 cites W1994890814 @default.
- W1983409097 cites W1999853913 @default.
- W1983409097 cites W2003052366 @default.
- W1983409097 cites W2003475613 @default.
- W1983409097 cites W2005416593 @default.
- W1983409097 cites W2008790845 @default.
- W1983409097 cites W2009411683 @default.
- W1983409097 cites W2009838390 @default.
- W1983409097 cites W2015711200 @default.
- W1983409097 cites W2016936675 @default.
- W1983409097 cites W2020213679 @default.
- W1983409097 cites W2023565873 @default.
- W1983409097 cites W2026223831 @default.
- W1983409097 cites W2027102959 @default.
- W1983409097 cites W2028067582 @default.
- W1983409097 cites W2033263952 @default.
- W1983409097 cites W2036976420 @default.
- W1983409097 cites W2039671512 @default.
- W1983409097 cites W2040669411 @default.
- W1983409097 cites W2043517738 @default.
- W1983409097 cites W2048470573 @default.
- W1983409097 cites W2056113570 @default.
- W1983409097 cites W2061477681 @default.
- W1983409097 cites W2066424213 @default.
- W1983409097 cites W2067673804 @default.
- W1983409097 cites W2070968636 @default.
- W1983409097 cites W2071646638 @default.
- W1983409097 cites W2073697610 @default.
- W1983409097 cites W2074289120 @default.
- W1983409097 cites W2087047837 @default.
- W1983409097 cites W2089577223 @default.
- W1983409097 cites W2091734258 @default.
- W1983409097 cites W2100492886 @default.
- W1983409097 cites W2103275378 @default.
- W1983409097 cites W2107608797 @default.
- W1983409097 cites W2109561093 @default.
- W1983409097 cites W2112022192 @default.
- W1983409097 cites W2112516812 @default.
- W1983409097 cites W2119673447 @default.
- W1983409097 cites W2124697228 @default.
- W1983409097 cites W2129506293 @default.
- W1983409097 cites W2132024398 @default.
- W1983409097 cites W2133208346 @default.
- W1983409097 cites W2137560810 @default.
- W1983409097 cites W2139644773 @default.
- W1983409097 cites W2144281413 @default.
- W1983409097 cites W2145396042 @default.
- W1983409097 cites W2145516138 @default.
- W1983409097 cites W2149038504 @default.
- W1983409097 cites W2149912429 @default.
- W1983409097 cites W2152904936 @default.
- W1983409097 cites W2161901878 @default.
- W1983409097 cites W2163498255 @default.
- W1983409097 cites W2180204563 @default.
- W1983409097 cites W2329252414 @default.
- W1983409097 cites W2332760096 @default.
- W1983409097 doi "https://doi.org/10.1080/15287394.2012.738457" @default.
- W1983409097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23294302" @default.
- W1983409097 hasPublicationYear "2013" @default.
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